Reaction profile

The FDA adverse-event record for pr-eye(s)/lid(s), lesion(s)

18 FDA adverse-event reports reference pr-eye(s)/lid(s), lesion(s) (VeDDRA 99612). See the species, breeds, and drugs most associated with it below.

18
reports citing this reaction
55.6%
death-coded share
Dog
most-affected species
Lufenuron + Milbemycin Oxime
most-associated drug
Verify with FDA CVM →
18
Total Reports
10
Deaths
55.6%
Death Rate

Species Most Affected

Dog 10
Cat 5
Sheep 1
Horse 1
Other Birds 1

Breeds Most Affected

Crossbred Canine/dog 2
British cat 2
Retriever - Labrador 1
Domestic (unspecified) 1
Domestic Shorthair 1
Sheep (unknown) 1
Maltese 1
Boxer (German Boxer) 1
Thoroughbred 1
Terrier - West Highland White 1

Associated Drugs

Lufenuron + Milbemycin Oxime 3
Cefovecin Sodium 2
Oclacitinib Maleate 2
Fluralaner Chew Tablets 2
Spinosad 1
Acepromazine Maleate 1
Amoxicillin 1
Robenacoxib 1
Butorphanol/Dexmeditomidine/Ketamine 1
Moxidectin 1
Dinotefuran/ Permethrin/ Pyriproxyfen 1
Prednisolone; Trimeprazine Tartrate 1
Tobramycin 1
Pergolide Mesylate 1
Selamectin 1
Canine Influenza Virus H3N8, Kv 1
Chlorhexidine Gluconate 3% 1
Cefpodoxime 1
Diphenhydramine Hcl 1
Loratidine 1

PR-EYE(S)/LID(S), LESION(S) Reaction Insights

18 reports name PR-EYE(S)/LID(S), LESION(S); 10 recorded a death outcome (55.6% of reported events, not a population-level mortality rate). VeDDRA code: 99612.

By species: Dog (10 reports), Cat (5 reports), Sheep (1 reports). By breed: Crossbred Canine/dog (2), British cat (2), Retriever - Labrador (1).

Most co-reported drugs: Lufenuron + Milbemycin Oxime (3 reports), Cefovecin Sodium (2 reports), Oclacitinib Maleate (2 reports), Fluralaner Chew Tablets (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.