Reaction profile

The FDA adverse-event record for pr-blood vessel(s), lesion(s)

30 FDA adverse-event reports reference pr-blood vessel(s), lesion(s) (VeDDRA 99591). See the species, breeds, and drugs most associated with it below.

30
reports citing this reaction
80.0%
death-coded share
Dog
most-affected species
Dexmedetomidine Hydrochloride
most-associated drug
Verify with FDA CVM →
30
Total Reports
24
Deaths
80.0%
Death Rate

Species Most Affected

Dog 18
Cat 7
Cattle 2
Horse 2
Human 1

Breeds Most Affected

Domestic (unspecified) 5
Appaloosa 2
Crossbred Canine/dog 2
Retriever - Labrador 2
Crossbred Bovine/Cattle 1
Siberian Husky 1
Unknown 1
Chihuahua 1
Ridgeback - Rhodesian 1
Terrier - Jack Russell 1

Associated Drugs

Dexmedetomidine Hydrochloride 4
Meloxicam 3
Xylazine 2
Cefovecin Sodium 2
Amoxicillin, Clavulanate 2
Maropitant Citrate 2
Selamectin 1
Ivermectin 1
Diclofenac 1
Enrofloxacin 1
Tiletamine, Zolazepam 1
Deracoxib 1
Moxidectin 1
Carprofen 1
Milbemycin Oxime + Spinosad 1
Maropitant 1
Ceftiofur Crystalline Free Acid 1
Glycosaminoglycan Polysulfate 1
Glucosamine/Methylsulfonylmethane/Chondrotin/Avocado-Soybean Unsaponifiables 1
Imidacloprid + Moxidectin 1

PR-BLOOD VESSEL(S), LESION(S) Reaction Insights

30 reports name PR-BLOOD VESSEL(S), LESION(S); 24 recorded a death outcome (80.0% of reported events, not a population-level mortality rate). VeDDRA code: 99591.

By species: Dog (18 reports), Cat (7 reports), Cattle (2 reports). By breed: Domestic (unspecified) (5), Appaloosa (2), Crossbred Canine/dog (2).

Most co-reported drugs: Dexmedetomidine Hydrochloride (4 reports), Meloxicam (3 reports), Xylazine (2 reports), Cefovecin Sodium (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.