Reaction profile

The FDA adverse-event record for portacaval shunt

31 FDA reports name portacaval shunt, a lower-volume reaction in the CVM extract (VeDDRA 504). Plate stamps and neighbourhood peers follow.

#1982 of 2,481
by report volume (all reactions)
31
reports citing this reaction
12.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Portacaval shunt has 31 reports now versus 31 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Portacaval shunt changes

FDA AER · VeDDRA plate

Code 504 VOL-TRACE

VOL-TRACE · DEATH-ELEV · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 31 reports
  • DEATH-ELEV 12.9%
  • LOWER-Q #1982/2481
  • PHOTO-FINISH ABNORMAL TEST RESULT,…
  • SPECIES-DOG Dog · 29
  • DRUG-LEAD Milbemycin Oxime… · 7
  • DESK-WIDE 14 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: ABNORMAL TEST RESULT, THYROID NOS (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Portacaval shunt

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ABNORMAL TEST RESULT,… · near31ALBUMIN HIGH, URINE · near31BILE ACIDS ABNORMAL,… · near31Clonic seizure · near31Portacaval shunt · this reac…31Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Portacaval shunt

What the FDA AER plate says about Portacaval shunt

Signature read: 31 reports place Portacaval shunt in the lower third of FDA AER volume (#1982 of 2,481). Report volume is lower-third scale: 31 named reports in the openFDA extract. 4 of 31 reports were death-coded (12.9% of named reports, not a population mortality rate). Nearest volume peer: ABNORMAL TEST RESULT, THYROID NOS (±0 reports). Lead species Dog (29). Lead co-reported drug Milbemycin Oxime + Spinosad (7).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 29
Cat 2

Breeds Most Affected

Terrier - Yorkshire 9
Maltese 6
Crossbred Canine/dog 3
Domestic Shorthair 2
Retriever - Golden 2
Shih Tzu 1
Terrier - Boston 1
Corgi - Welsh Cardigan 1
Spaniel - Cocker English 1
Spaniel (unspecified) 1

Associated Drugs

Milbemycin Oxime + Spinosad 7
Imidacloprid + Moxidectin 3
Spinosad 3
Afoxolaner 2
Ivermectin + Pyrantel As Pamoate Salt 2
Oclacitinib Maleate 2
Milbemycin Oxime 2
Milbemycin Oxime + Praziquantel 2
Vaccination 1
Praziquantel/Pyrantel Pamoate/Febantel 1
S-Adenosylmethionine And Silybin 1
Unspecified Antibiotics 1
Diazepam 1
Unknown Intravenous Fluids 1
Vaccines (Unknown) 1
Antibiotic (Unknown) 1
Fenbendazol Granules 1
Cefpodoxime Proxetil 1
Terbinafine Hcl 1
Fluralaner Chew Tablets 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Portacaval shunt (#1982 of 2,481 by report volume); death-coded 12.9%. PlainBreed reaction plate · report volume stamp 31 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →