Reaction profile

The FDA adverse-event record for portacaval shunt

31 FDA adverse-event reports reference portacaval shunt (VeDDRA 504). See the species, breeds, and drugs most associated with it below.

31
reports citing this reaction
12.9%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
31
Total Reports
4
Deaths
12.9%
Death Rate

Species Most Affected

Dog 29
Cat 2

Breeds Most Affected

Terrier - Yorkshire 9
Maltese 6
Crossbred Canine/dog 3
Domestic Shorthair 2
Retriever - Golden 2
Shih Tzu 1
Terrier - Boston 1
Corgi - Welsh Cardigan 1
Spaniel - Cocker English 1
Spaniel (unspecified) 1

Associated Drugs

Milbemycin Oxime + Spinosad 7
Imidacloprid + Moxidectin 3
Spinosad 3
Afoxolaner 2
Ivermectin + Pyrantel As Pamoate Salt 2
Oclacitinib Maleate 2
Milbemycin Oxime 2
Milbemycin Oxime + Praziquantel 2
Vaccination 1
Praziquantel/Pyrantel Pamoate/Febantel 1
S-Adenosylmethionine And Silybin 1
Unspecified Antibiotics 1
Diazepam 1
Unknown Intravenous Fluids 1
Fenbendazol Granules 1
Vaccines (Unknown) 1
Antibiotic (Unknown) 1
Cefpodoxime Proxetil 1
Terbinafine Hcl 1
Fluralaner Chew Tablets 1

Portacaval shunt Reaction Insights

31 reports name Portacaval shunt; 4 recorded a death outcome (12.9% of reported events, not a population-level mortality rate). VeDDRA code: 504.

By species: Dog (29 reports), Cat (2 reports). By breed: Terrier - Yorkshire (9), Maltese (6), Crossbred Canine/dog (3).

Most co-reported drugs: Milbemycin Oxime + Spinosad (7 reports), Imidacloprid + Moxidectin (3 reports), Spinosad (3 reports), Afoxolaner (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.