Reaction profile

The FDA adverse-event record for pituitary disorder nos

39 FDA adverse-event reports reference pituitary disorder nos (VeDDRA 402). See the species, breeds, and drugs most associated with it below.

39
reports citing this reaction
46.2%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
39
Total Reports
18
Deaths
46.2%
Death Rate

Species Most Affected

Dog 33
Horse 4
Cat 2

Breeds Most Affected

Boxer (German Boxer) 6
Retriever - Golden 4
Retriever - Labrador 3
Terrier - Boston 3
Shepherd Dog - Australian 2
Spaniel (unspecified) 2
American Pit Bull Terrier 2
Dachshund (unspecified) 1
Beagle 1
Domestic Longhair 1

Associated Drugs

Trilostane 36
Milbemycin Oxime + Spinosad 4
Imidacloprid + Moxidectin 2
Fluralaner Chew Tablets 2
Grapiprant 2
Omeprazole 2
Probiotic 2
Unspecified Steroid Cream 1
Bismuth Subsalicylate 1
Antibiotic (Unknown) 1
Neem Oil 1
Diazepam 1
Intravenous Lipid Emulsion 1
Phenobarbital 1
Posatex Otic Suspension 1
Moxidectin 1
Insulin Injectable Vial 1
N-Butylscopolaminium Bromide 1
Eastern Encephalomyelitis Virus, Killed Virus + Tetanus Toxoid + West Nile Virus, Killed Virus + Western Encephalomyelitis Virus, Killed Virus 1
Sarolaner 1

Pituitary disorder NOS Reaction Insights

39 reports name Pituitary disorder NOS; 18 recorded a death outcome (46.2% of reported events, not a population-level mortality rate). VeDDRA code: 402.

By species: Dog (33 reports), Horse (4 reports), Cat (2 reports). By breed: Boxer (German Boxer) (6), Retriever - Golden (4), Retriever - Labrador (3).

Most co-reported drugs: Trilostane (36 reports), Milbemycin Oxime + Spinosad (4 reports), Imidacloprid + Moxidectin (2 reports), Fluralaner Chew Tablets (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.