Reaction profile

The FDA adverse-event record for periorbital oedema (see also immune system disorders)

Name: Periorbital oedema (see also Immune system disorders) - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

13 FDA reports name periorbital oedema (see also immune system disorders), a lower-volume reaction in the CVM extract (VeDDRA 460). Plate stamps and neighbourhood peers follow.

#2366 of 2,481
by report volume (all reactions): 13
reports citing this reaction: 0.0%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

FDA AER · VeDDRA plate

Code 460 VOL-TRACE

VOL-TRACE · DEATH-RARE · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 13 reports
DEATH-RARE 0.0%
BOTTOM-DECILE #2366/2481
PHOTO-FINISH Abnormal digital pulse
SPECIES-DOG Dog · 12
DRUG-LEAD Moxidectin · 4
DESK-WIDE 11 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal digital pulse (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Periorbital oedema

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Periorbital oedema (see also Immune system disorders)

Periorbital oedema (see also Immune system disorders): low death-coded share in the FDA AER plate

Signature read: 13 reports place Periorbital oedema (see also Immune system disorders) in the lower third of FDA AER volume (#2366 of 2,481). Report volume is lower-third scale: 13 named reports in the openFDA extract. Death-coded share is lower-third: 0 of 13 reports (0.0% of named reports). Nearest volume peer: Abnormal digital pulse (±0 reports). Lead species Dog (12). Lead co-reported drug Moxidectin (4).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 12

Cat 1

Breeds Most Affected

Retriever - Labrador 2

Chihuahua 2

American Pit Bull Terrier 1

Siberian Husky 1

Domestic Shorthair 1

Shih Tzu 1

Maltese 1

Boxer (German Boxer) 1

Crossbred Canine/dog 1

Bulldog - English 1

Associated Drugs

Moxidectin 4

Rabies Virus, Kv 3

Lotilaner 2

Fluralaner Powder For Inj Susp 2

Ilunocitinib 1

Anti-Il31 Mab Mcs Lot #1283563 1

Dapp Vaccine Another Manufacturer 1

Cephalexin 1

Sterile Honey Veterinary Wound Dressing Gel 1

Silver Sulfadiazine 1

Allergy Supplement (Unknown) 1

Ivermectin + Pyrantel 1

Selamectin;Sarolaner 1

Cefovecin 1

Fluoxetine 1

Gentamicin And Betamethasone Spray 1

Chlorhexidine Digluconate, 3 Percent, Wipes 1

Nystatin, Neomycin, Thiostrepton, Triamcinolone 1

Famciclovir 1

Rabies Vaccine 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Periorbital oedema (see also Immune system disorders) (#2366 of 2,481 by report volume); death-coded 0.0%. PlainBreed reaction plate · report volume stamp 13 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →