Reaction profile

The FDA adverse-event record for perinatal mortality

14 FDA adverse-event reports reference perinatal mortality (VeDDRA 1686). See the species, breeds, and drugs most associated with it below.

14
reports citing this reaction
57.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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14
Total Reports
8
Deaths
57.1%
Death Rate

Species Most Affected

Dog 12
Pig 2

Breeds Most Affected

Mountain Dog - Bernese 2
Bulldog - French 1
Spaniel - King Charles Cavalier 1
Terrier - Yorkshire 1
Schnauzer - Miniature 1
Rottweiler 1
Pig (unknown) 1
Crossbred Porcine/Pig 1
Retriever - Labrador 1
Boxer (German Boxer) 1

Associated Drugs

Milbemycin Oxime + Spinosad 3
Afoxolaner 3
Fluralaner Chew Tablets 3
Selamectin 2
5-Way Vaccine (Unknown) 1
Spinosad 1
Tiamulin Hydrogen Fumarate 1
Ivermectin 1
Ivermectin + Pyrantel As Pamoate Salt 1

Perinatal mortality Reaction Insights

14 reports name Perinatal mortality; 8 recorded a death outcome (57.1% of reported events, not a population-level mortality rate). VeDDRA code: 1686.

By species: Dog (12 reports), Pig (2 reports). By breed: Mountain Dog - Bernese (2), Bulldog - French (1), Spaniel - King Charles Cavalier (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (3 reports), Afoxolaner (3 reports), Fluralaner Chew Tablets (3 reports), Selamectin (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.