Reaction profile

The FDA adverse-event record for penile protrusion

13 FDA adverse-event reports reference penile protrusion (VeDDRA 2100). See the species, breeds, and drugs most associated with it below.

13
reports citing this reaction
15.4%
death-coded share
Dog
most-affected species
Trenbolone Acetate;Estradiol Benzoate
most-associated drug
Verify with FDA CVM →
13
Total Reports
2
Deaths
15.4%
Death Rate

Species Most Affected

Dog 7
Cattle 4
Horse 2

Breeds Most Affected

Mixed (Cattle) 4
Poodle - Miniature 1
Terrier - West Highland White 1
Bulldog 1
Warmblood (unspecified) 1
Pony (unspecified) 1
Spitz - German Pomeranian 1
Boxer (German Boxer) 1
Dog (unknown) 1
Poodle - Toy 1

Associated Drugs

Trenbolone Acetate;Estradiol Benzoate 5
Carprofen 3
Acepromazine 2
Pergolide Mesylate 2
Bedinvetmab 2
Nitenpyram 1
Spinosad 1
Cyclosporine 1
Buprenorphine 1
Ketamine 1
Diazepam 1
Isoflurane 1
Lactated Ringer&Apos;S Solution 1
Progesterone;Estradiol Benzoate 1
Trenbolone Acetate & Estradiol 1
Oclacitinib Maleate 1
Pyrantel Pamoate;Sarolaner 1

Penile protrusion Reaction Insights

13 reports name Penile protrusion; 2 recorded a death outcome (15.4% of reported events, not a population-level mortality rate). VeDDRA code: 2100.

By species: Dog (7 reports), Cattle (4 reports), Horse (2 reports). By breed: Mixed (Cattle) (4), Poodle - Miniature (1), Terrier - West Highland White (1).

Most co-reported drugs: Trenbolone Acetate;Estradiol Benzoate (5 reports), Carprofen (3 reports), Acepromazine (2 reports), Pergolide Mesylate (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.