Reaction profile

The FDA adverse-event record for penile protrusion

13 FDA reports name penile protrusion, a lower-volume reaction in the CVM extract (VeDDRA 2100). Plate stamps and neighbourhood peers follow.

#2365 of 2,481
by report volume (all reactions)
13
reports citing this reaction
15.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Penile protrusion has 13 reports now versus 13 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Penile protrusion changes

FDA AER · VeDDRA plate

Code 2100 VOL-TRACE

VOL-TRACE · DEATH-ELEV · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 13 reports
  • DEATH-ELEV 15.4%
  • BOTTOM-DECILE #2365/2481
  • PHOTO-FINISH Abnormal digital pulse
  • SPECIES-DOG Dog · 7
  • DRUG-LEAD Trenbolone Acetat… · 5
  • DESK-WIDE 10 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal digital pulse (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Penile protrusion

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal digital pulse · near13Acute haemorrhagic pa… · near13Acute jaundice · near13Application site mass… · near13Penile protrusion · this rea…13Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Penile protrusion

What the FDA AER plate says about Penile protrusion

Signature read: 13 reports place Penile protrusion in the lower third of FDA AER volume (#2365 of 2,481). Report volume is lower-third scale: 13 named reports in the openFDA extract. 2 of 13 reports were death-coded (15.4% of named reports, not a population mortality rate). Nearest volume peer: Abnormal digital pulse (±0 reports). Lead species Dog (7). Lead co-reported drug Trenbolone Acetate;Estradiol Benzoate (5).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trenbolone Acetate;Estradiol Benzoate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 7
Cattle 4
Horse 2

Breeds Most Affected

Mixed (Cattle) 4
Poodle - Miniature 1
Terrier - West Highland White 1
Bulldog 1
Warmblood (unspecified) 1
Pony (unspecified) 1
Spitz - German Pomeranian 1
Boxer (German Boxer) 1
Poodle - Toy 1
Dog (unknown) 1

Associated Drugs

Trenbolone Acetate;Estradiol Benzoate 5
Carprofen 3
Acepromazine 2
Pergolide Mesylate 2
Bedinvetmab 2
Nitenpyram 1
Spinosad 1
Cyclosporine 1
Buprenorphine 1
Ketamine 1
Diazepam 1
Isoflurane 1
Lactated Ringer&Apos;S Solution 1
Trenbolone Acetate & Estradiol 1
Progesterone;Estradiol Benzoate 1
Oclacitinib Maleate 1
Pyrantel Pamoate;Sarolaner 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Penile protrusion (#2365 of 2,481 by report volume); death-coded 15.4%. PlainBreed reaction plate · report volume stamp 13 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →