Reaction profile

The FDA adverse-event record for papillary necrosis

10 FDA adverse-event reports reference papillary necrosis (VeDDRA 1253). See the species, breeds, and drugs most associated with it below.

10
reports citing this reaction
100.0%
death-coded share
Dog
most-affected species
Firocoxib
most-associated drug
Verify with FDA CVM →
10
Total Reports
10
Deaths
100.0%
Death Rate

Species Most Affected

Dog 6
Horse 2
Cat 2

Breeds Most Affected

Quarter Horse 2
Crossbred Canine/dog 2
Great Pyrenees 2
Shepherd Dog - German 1
Domestic Mediumhair 1
Poodle - Standard 1
Domestic Shorthair 1

Associated Drugs

Firocoxib 2
Milbemycin Oxime + Spinosad 1
Diethylstilbestrol (Des) 1
Phenylpropanolamine (Unknown) 1
Pancrelipase 1
Gentamicin 1
Xylazine 1
Penicillin G Potassium 1
Phenylbutazone 1
Meloxicam 1
Delmopinol 35 Mg Oral Chewable Tablet 1
Oravet Plaque Prevention Gel 1
Fluralaner Chew Tablets 1
Fenbendazol Granules 1
Proin 1
Mirtazipine 1
Ondansetron 1
Iv Fluids 1
Outpatient Treatments (Unknown) 1
Carprofen 1

Papillary necrosis Reaction Insights

10 reports name Papillary necrosis; 10 recorded a death outcome (100.0% of reported events, not a population-level mortality rate). VeDDRA code: 1253.

By species: Dog (6 reports), Horse (2 reports), Cat (2 reports). By breed: Quarter Horse (2), Crossbred Canine/dog (2), Great Pyrenees (2).

Most co-reported drugs: Firocoxib (2 reports), Milbemycin Oxime + Spinosad (1 reports), Diethylstilbestrol (Des) (1 reports), Phenylpropanolamine (Unknown) (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.