Reaction profile

The FDA adverse-event record for papillary necrosis

Name: Papillary necrosis - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

10 FDA reports name papillary necrosis, a lower-volume reaction in the CVM extract (VeDDRA 1253). Plate stamps and neighbourhood peers follow.

#2466 of 2,481
by report volume (all reactions): 10
reports citing this reaction: 100.0%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Papillary necrosis has 10 reports now versus 10 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Papillary necrosis changes

FDA AER · VeDDRA plate

Code 1253 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-MID · BOOK-FULL

VOL-TRACE 10 reports
DEATH-HOT 100.0%
BOTTOM-DECILE #2466/2481
PHOTO-FINISH Anoxia
SPECIES-DOG Dog · 6
DRUG-LEAD Firocoxib · 2
DESK-MID 7 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Anoxia (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Papillary necrosis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Papillary necrosis

Papillary necrosis: high death-coded share in the FDA AER plate

Signature read: Papillary necrosis's 100.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 10 named reports in the openFDA extract. Death-coded share is upper-third: 10 of 10 reports (100.0% of named reports). Nearest volume peer: Anoxia (±0 reports). Lead species Dog (6). Lead co-reported drug Firocoxib (2).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 6

Horse 2

Cat 2

Breeds Most Affected

Quarter Horse 2

Crossbred Canine/dog 2

Great Pyrenees 2

Shepherd Dog - German 1

Domestic Mediumhair 1

Poodle - Standard 1

Domestic Shorthair 1

Associated Drugs

Firocoxib 2

Milbemycin Oxime + Spinosad 1

Diethylstilbestrol (Des) 1

Phenylpropanolamine (Unknown) 1

Pancrelipase 1

Gentamicin 1

Xylazine 1

Penicillin G Potassium 1

Phenylbutazone 1

Fluralaner Chew Tablets 1

Fenbendazol Granules 1

Proin 1

Mirtazipine 1

Ondansetron 1

Iv Fluids 1

Outpatient Treatments (Unknown) 1

Carprofen 1

Meloxicam 1

Delmopinol 35 Mg Oral Chewable Tablet 1

Oravet Plaque Prevention Gel 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Papillary necrosis (#2466 of 2,481 by report volume); death-coded 100.0%. PlainBreed reaction plate · death-coded share stamp 100.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →