Reaction profile

The FDA adverse-event record for pancreas endocrine disorder nos

32 FDA adverse-event reports reference pancreas endocrine disorder nos (VeDDRA 396). See the species, breeds, and drugs most associated with it below.

32
reports citing this reaction
53.1%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
32
Total Reports
17
Deaths
53.1%
Death Rate

Species Most Affected

Dog 23
Cat 9

Breeds Most Affected

Domestic Shorthair 4
Rottweiler 2
Shepherd Dog - German 2
Schnauzer - Miniature 2
Retriever - Golden 2
Domestic Mediumhair 2
Collie - Border 2
Setter - Irish Red 1
Pit Bull 1
Retriever - Labrador 1

Associated Drugs

Afoxolaner 6
Milbemycin Oxime + Spinosad 4
Maropitant Citrate 4
Ivermectin + Pyrantel As Pamoate Salt 3
Carprofen 2
Rabies Vaccine 2
Prednisone 2
Emodepside + Praziquantel 2
Fluids 2
Spinosad 2
Meloxicam 2
Ivermectin 1
Spinosad; Milbemycin Oxime 1
Fish Oil 1
Trilostane 1
Vetsulin 1
Cefovecin 1
Imidacloprid + Moxidectin 1
Unknown Antibiotic 1
Unspecified Shampoo 1

Pancreas endocrine disorder NOS Reaction Insights

32 reports name Pancreas endocrine disorder NOS; 17 recorded a death outcome (53.1% of reported events, not a population-level mortality rate). VeDDRA code: 396.

By species: Dog (23 reports), Cat (9 reports). By breed: Domestic Shorthair (4), Rottweiler (2), Shepherd Dog - German (2).

Most co-reported drugs: Afoxolaner (6 reports), Milbemycin Oxime + Spinosad (4 reports), Maropitant Citrate (4 reports), Ivermectin + Pyrantel As Pamoate Salt (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.