Reaction profile

The FDA adverse-event record for palpebral oedema

12 FDA adverse-event reports reference palpebral oedema (VeDDRA 420). See the species, breeds, and drugs most associated with it below.

12
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species
Lufenuron + Milbemycin Oxime
most-associated drug
Verify with FDA CVM →
12
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Dog 7
Cat 3
Human 1
Cattle 1

Breeds Most Affected

Spaniel - Irish Water 1
Domestic Shorthair 1
Chihuahua 1
Unknown 1
Lhasa Apso 1
Bulldog 1
Terrier - Boston 1
Dachshund (unspecified) 1
Persian 1
Shih Tzu 1

Associated Drugs

Lufenuron + Milbemycin Oxime 3
Milbemycin Oxime + Spinosad 2
Cyclosporine A 1
Fipronil 1
Ivermectin 1
Robenacoxib 1
Ketamine 1
Vaccinations 1
Xylazine 1
Imidacloprid + Moxidectin 1
Unknown Soap 1
Maropitant Citrate 1
Hyaluronic Acid 1
Tobramycin 1
Antibiotic 1
Artificial Tear Solution 1
Unknown Ocular Solution 1
Cyclosporin Ointment 1
Frunevetmab 1
Doramectin 1

Palpebral oedema Reaction Insights

12 reports name Palpebral oedema; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 420.

By species: Dog (7 reports), Cat (3 reports), Human (1 reports). By breed: Spaniel - Irish Water (1), Domestic Shorthair (1), Chihuahua (1).

Most co-reported drugs: Lufenuron + Milbemycin Oxime (3 reports), Milbemycin Oxime + Spinosad (2 reports), Cyclosporine A (1 reports), Fipronil (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.