Reaction profile

The FDA adverse-event record for nt - hepatic lipidosis (steatosis)

31 FDA adverse-event reports reference nt - hepatic lipidosis (steatosis) (VeDDRA 2321). See the species, breeds, and drugs most associated with it below.

31
reports citing this reaction
90.3%
death-coded share
Cat
most-affected species
Fluralaner Chew Tablets
most-associated drug
Verify with FDA CVM →
31
Total Reports
28
Deaths
90.3%
Death Rate

Species Most Affected

Cat 15
Dog 13
Sheep 1
Cattle 1
Horse 1

Breeds Most Affected

Domestic Shorthair 10
Crossbred Canine/dog 4
Sheep (unknown) 1
Sheepdog - Shetland 1
Chihuahua 1
Crossbred Feline/cat 1
Persian 1
Spaniel - King Charles Cavalier 1
Spitz - German Pomeranian 1
Dog (other) 1

Associated Drugs

Fluralaner Chew Tablets 6
Afoxolaner 3
Fluralaner Spot-On Solution 3
Water, Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride 3
Cefovecin 2
Ivermectin + Pyrantel As Pamoate Salt 2
Maropitant Citrate 2
Selamectin;Sarolaner 2
Oxfendazole 1
Dexmedetomidine Hydrochloride 1
Ketamine Hydrochloride 1
Butorphanol Tartrate 1
Marbofloxacin 1
Cyproheptadine Hcl 1
Hydromorphone Hcl 1
Cyclosporine A 1
Oclacitinib Maleate 1
Midazolam Hydrochloride 1
Nitenpyram 1
Fenbendazole 1

NT - hepatic lipidosis (steatosis) Reaction Insights

31 reports name NT - hepatic lipidosis (steatosis); 28 recorded a death outcome (90.3% of reported events, not a population-level mortality rate). VeDDRA code: 2321.

By species: Cat (15 reports), Dog (13 reports), Sheep (1 reports). By breed: Domestic Shorthair (10), Crossbred Canine/dog (4), Sheep (unknown) (1).

Most co-reported drugs: Fluralaner Chew Tablets (6 reports), Afoxolaner (3 reports), Fluralaner Spot-On Solution (3 reports), Water, Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.