Reaction profile

The FDA adverse-event record for neurological pain nos

48 FDA reports name neurological pain nos, a lower-volume reaction in the CVM extract (VeDDRA 1647). Plate stamps and neighbourhood peers follow.

#1760 of 2,481
by report volume (all reactions)
48
reports citing this reaction
18.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Neurological pain NOS has 48 reports now versus 47 in that prior snapshot: 1 more (2.1%).

Report change
+1
Death-coded reports
+0
Death-coded share
−0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Neurological pain NOS changes

FDA AER · VeDDRA plate

Code 1647 VOL-TRACE

VOL-TRACE · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 48 reports
  • DEATH-ELEV 18.8%
  • MID-PACK #1760/2481
  • PHOTO-FINISH Abnormal echocardiogr…
  • SPECIES-DOG Dog · 47
  • DRUG-LEAD Milbemycin Oxime… · 7
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal echocardiogram (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Neurological pain NOS

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal echocardiogr… · near48Application site absc… · near48Brain damage NOS · near48Brain tumour · near48Neurological pain NOS · this…48Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Neurological pain NOS

What the FDA AER plate says about Neurological pain NOS

Signature read: 48 reports place Neurological pain NOS in the lower third of FDA AER volume (#1760 of 2,481). Report volume is lower-third scale: 48 named reports in the openFDA extract. 9 of 48 reports were death-coded (18.8% of named reports, not a population mortality rate). Nearest volume peer: Abnormal echocardiogram (±0 reports). Lead species Dog (47). Lead co-reported drug Milbemycin Oxime + Spinosad (7).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 47
Human 1

Breeds Most Affected

Chihuahua 5
Spaniel - King Charles Cavalier 5
Pit Bull 2
Retriever - Labrador 2
Schnauzer - Miniature 2
Crossbred Canine/dog 2
Pinscher - Miniature 2
Sheepdog - Long-haired Pyrenean 2
Dog (unknown) 1
Poodle - Miniature 1

Associated Drugs

Milbemycin Oxime + Spinosad 7
Afoxolaner 7
Spinosad 6
Pimobendan 5
Gabapentin 4
Trilostane 4
Prednisone 3
Vetmedin Pimobendan Chewable 2.5 Mg Np 3
Fipronil 2
Ivermectin 2
Milbemycin Oxime + Praziquantel 2
Oclacitinib Maleate 2
Afoxolaner 28.3 Mg Chewable Tablets 2
Bedinvetmab 2
Dexamethasone Sodium Phosphate 2
Pyrantel Pamoate 1
Metronidazole 1
Milbemycin Oxime + Lufenuron 1
Insulin Injectable Vial 1
Ivermectin + Pyrantel 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Neurological pain NOS (#1760 of 2,481 by report volume); death-coded 18.8%. PlainBreed reaction plate · report volume stamp 48 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →