Reaction profile

The FDA adverse-event record for neurological pain nos

47 FDA adverse-event reports reference neurological pain nos (VeDDRA 1647). See the species, breeds, and drugs most associated with it below.

47
reports citing this reaction
19.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
47
Total Reports
9
Deaths
19.1%
Death Rate

Species Most Affected

Dog 46
Human 1

Breeds Most Affected

Spaniel - King Charles Cavalier 5
Chihuahua 4
Pit Bull 2
Retriever - Labrador 2
Schnauzer - Miniature 2
Crossbred Canine/dog 2
Pinscher - Miniature 2
Sheepdog - Long-haired Pyrenean 2
Poodle - Miniature 1
Dog (unknown) 1

Associated Drugs

Milbemycin Oxime + Spinosad 7
Afoxolaner 7
Spinosad 6
Pimobendan 5
Gabapentin 4
Trilostane 4
Prednisone 3
Vetmedin Pimobendan Chewable 2.5 Mg Np 3
Fipronil 2
Ivermectin 2
Milbemycin Oxime + Praziquantel 2
Oclacitinib Maleate 2
Afoxolaner 28.3 Mg Chewable Tablets 2
Bedinvetmab 2
Dexamethasone Sodium Phosphate 2
Pyrantel Pamoate 1
Metronidazole 1
Milbemycin Oxime + Lufenuron 1
Insulin Injectable Vial 1
Ivermectin + Pyrantel 1

Neurological pain NOS Reaction Insights

47 reports name Neurological pain NOS; 9 recorded a death outcome (19.1% of reported events, not a population-level mortality rate). VeDDRA code: 1647.

By species: Dog (46 reports), Human (1 reports). By breed: Spaniel - King Charles Cavalier (5), Chihuahua (4), Pit Bull (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (7 reports), Afoxolaner (7 reports), Spinosad (6 reports), Pimobendan (5 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.