Reaction profile

The FDA adverse-event record for nail discolouration

14 FDA adverse-event reports reference nail discolouration (VeDDRA 1632). See the species, breeds, and drugs most associated with it below.

14
reports citing this reaction
0.0%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
14
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Dog 9
Human 5

Breeds Most Affected

Unknown 5
Terrier (unspecified) 2
Terrier - Bull - American Pit 2
Poodle (unspecified) 1
Chihuahua 1
Pinscher - Miniature 1
Bulldog - French 1
Dachshund (unspecified) 1

Associated Drugs

Oclacitinib Maleate 4
Imidacloprid, Moxidectin 2
Milbemycin Oxime + Spinosad 2
Selamectin 1
Omeprazole 1
Ivermectin 34Mcg, Pyrantel Pamoate 28.5Mg, Praziquantel 28.5Mg 1
Pimobendan 1
Spinosad 1
Cefaclor 1
Afoxolaner 1
Ketoconazole 1
Melarsomine Dihydrochloride 1
Prednisone 1
Trazodone Hcl 1
Acetylsalicylic Acid 1
Sarolaner 1
Heartguard 1
Fish Oil Unspecified 1
Probiotic Unspecified 1

Nail discolouration Reaction Insights

14 reports name Nail discolouration; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 1632.

By species: Dog (9 reports), Human (5 reports). By breed: Unknown (5), Terrier (unspecified) (2), Terrier - Bull - American Pit (2).

Most co-reported drugs: Oclacitinib Maleate (4 reports), Imidacloprid, Moxidectin (2 reports), Milbemycin Oxime + Spinosad (2 reports), Selamectin (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.