Reaction profile

The FDA adverse-event record for myoglobinuria

20 FDA adverse-event reports reference myoglobinuria (VeDDRA 2056). See the species, breeds, and drugs most associated with it below.

20
reports citing this reaction
40.0%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
20
Total Reports
8
Deaths
40.0%
Death Rate

Species Most Affected

Dog 17
Horse 2
Cat 1

Breeds Most Affected

Shepherd Dog - German 4
Chihuahua 3
Retriever - Labrador 2
Quarter Horse 1
Domestic Shorthair 1
Horse (unknown) 1
Boxer (German Boxer) 1
Schipperke 1
Schnauzer (unspecified) 1
Retriever - Golden 1

Associated Drugs

Moxidectin 4
Polysulfated Glycosaminoglycan 2
Afoxolaner 2
Carprofen 2
Doxycycline 2
Bedinvetmab 2
Gabapentin 2
Cefovecin Sodium 1
Cefovecin 1
Clenbuterol Hydrochloride 1
Milbemcyin Oxime, Lufenuron, Praziquantel 1
Firocoxib 57 Mg Chewable 1
Afoxolaner 68 Mg Chewable Tablets 1
Ibuprofen 1
Tramadol 1
Glucosamine/Chondroitin With Avocado/Soybean Unsaponifiables 1
Butorphanol Tartrate 1
Dexmedetomidine 1
Atipameole Hcl 1
Famotidine 1

Myoglobinuria Reaction Insights

20 reports name Myoglobinuria; 8 recorded a death outcome (40.0% of reported events, not a population-level mortality rate). VeDDRA code: 2056.

By species: Dog (17 reports), Horse (2 reports), Cat (1 reports). By breed: Shepherd Dog - German (4), Chihuahua (3), Retriever - Labrador (2).

Most co-reported drugs: Moxidectin (4 reports), Polysulfated Glycosaminoglycan (2 reports), Afoxolaner (2 reports), Carprofen (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.