Reaction profile

The FDA adverse-event record for metabolism and nutrition disorder nos

17 FDA adverse-event reports reference metabolism and nutrition disorder nos (VeDDRA 2019). See the species, breeds, and drugs most associated with it below.

17
reports citing this reaction
47.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
17
Total Reports
8
Deaths
47.1%
Death Rate

Species Most Affected

Dog 10
Cattle 4
Unknown 1
Turkey 1
Horse 1

Breeds Most Affected

Chihuahua 2
Cattle (other) 2
Boxer (German Boxer) 2
Sheepdog - Shetland 1
Poodle - Standard 1
Unknown 1
Schnauzer - Miniature 1
Dachshund - Miniature 1
Mixed (Cattle) 1
Brangus 1

Associated Drugs

Milbemycin Oxime + Spinosad 3
Imidacloprid + Moxidectin 1
Tulathromycin 1
Spinosad 1
Milbemycin Oxime 1
Tylosin Tartrate 1
Alprazolam 1
Trilostane 1
Sam-E 1
Pyrantel Pamoate/Praziquantel 1
Decoquinate 1
Lasalocid Sodium 1
Doramectin 1
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 1
Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Infectious Bovine Rhinotra 1
Afoxolaner 1
Selamectin 1
Propofol 1
Isoflurane 1
Monensin Sodium 1

Metabolism and nutrition disorder NOS Reaction Insights

17 reports name Metabolism and nutrition disorder NOS; 8 recorded a death outcome (47.1% of reported events, not a population-level mortality rate). VeDDRA code: 2019.

By species: Dog (10 reports), Cattle (4 reports), Unknown (1 reports). By breed: Chihuahua (2), Cattle (other) (2), Boxer (German Boxer) (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (3 reports), Imidacloprid + Moxidectin (1 reports), Tulathromycin (1 reports), Spinosad (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.