Reaction profile

The FDA adverse-event record for malignant hyperthermia

Name: Malignant hyperthermia - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

13 FDA reports name malignant hyperthermia, a lower-volume reaction in the CVM extract (VeDDRA 1013). Plate stamps and neighbourhood peers follow.

#2362 of 2,481
by report volume (all reactions): 13
reports citing this reaction: 38.5%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Malignant hyperthermia has 13 reports now versus 13 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Malignant hyperthermia changes

FDA AER · VeDDRA plate

Code 1013 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 13 reports
DEATH-HOT 38.5%
BOTTOM-DECILE #2362/2481
PHOTO-FINISH Abnormal digital pulse
SPECIES-DOG Dog · 9
DRUG-LEAD Isoflurane · 7
DESK-WIDE 10 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal digital pulse (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Malignant hyperthermia

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Malignant hyperthermia

Malignant hyperthermia: high death-coded share in the FDA AER plate

Signature read: 13 reports place Malignant hyperthermia in the lower third of FDA AER volume (#2362 of 2,481). Report volume is lower-third scale: 13 named reports in the openFDA extract. Death-coded share is upper-third: 5 of 13 reports (38.5% of named reports). Nearest volume peer: Abnormal digital pulse (±0 reports). Lead species Dog (9). Lead co-reported drug Isoflurane (7).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 9

Cat 3

Other 1

Breeds Most Affected

Domestic Shorthair 2

Unknown 2

Retriever - Labrador 2

Cattle Dog - Flanders (Bouvier) 1

Siberian Husky 1

Domestic Longhair 1

Pug 1

Crossbred Canine/dog 1

Hovawart 1

Retriever - Golden 1

Associated Drugs

Isoflurane 7

Propofol 5

Butorphanol 4

Buprenorphine 4

Dexmedetomidine 3

Ketamine 3

Atropine 2

Acepromazine 2

Midazolam 2

Carprofen 1

Dexmedetomidine Hydrochloride 1

Robenacoxib 1

Isoflurane Anesthesia 1

Famotidine 1

Diazepam 1

Epinephrine 1

Midazolam Hydrochloride 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Malignant hyperthermia (#2362 of 2,481 by report volume); death-coded 38.5%. PlainBreed reaction plate · report volume stamp 13 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →