Reaction profile

The FDA adverse-event record for malignant hyperthermia

13 FDA adverse-event reports reference malignant hyperthermia (VeDDRA 1013). See the species, breeds, and drugs most associated with it below.

13
reports citing this reaction
38.5%
death-coded share
Dog
most-affected species
Isoflurane
most-associated drug
Verify with FDA CVM →
13
Total Reports
5
Deaths
38.5%
Death Rate

Species Most Affected

Dog 9
Cat 3
Other 1

Breeds Most Affected

Domestic Shorthair 2
Unknown 2
Retriever - Labrador 2
Cattle Dog - Flanders (Bouvier) 1
Siberian Husky 1
Domestic Longhair 1
Pug 1
Crossbred Canine/dog 1
Retriever - Golden 1
Hovawart 1

Associated Drugs

Isoflurane 7
Propofol 5
Butorphanol 4
Buprenorphine 4
Dexmedetomidine 3
Ketamine 3
Atropine 2
Acepromazine 2
Midazolam 2
Carprofen 1
Dexmedetomidine Hydrochloride 1
Robenacoxib 1
Isoflurane Anesthesia 1
Famotidine 1
Diazepam 1
Epinephrine 1
Midazolam Hydrochloride 1

Malignant hyperthermia Reaction Insights

13 reports name Malignant hyperthermia; 5 recorded a death outcome (38.5% of reported events, not a population-level mortality rate). VeDDRA code: 1013.

By species: Dog (9 reports), Cat (3 reports), Other (1 reports). By breed: Domestic Shorthair (2), Unknown (2), Retriever - Labrador (2).

Most co-reported drugs: Isoflurane (7 reports), Propofol (5 reports), Butorphanol (4 reports), Buprenorphine (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.