Reaction profile

The FDA adverse-event record for low liver enzymes nos

12 FDA adverse-event reports reference low liver enzymes nos (VeDDRA 2689). See the species, breeds, and drugs most associated with it below.

12
reports citing this reaction
8.3%
death-coded share
Cat
most-affected species
Robenacoxib
most-associated drug
Verify with FDA CVM →
12
Total Reports
1
Deaths
8.3%
Death Rate

Species Most Affected

Cat 6
Dog 6

Breeds Most Affected

Domestic Shorthair 3
Spaniel - King Charles Cavalier 2
Schnauzer (unspecified) 2
Ragdoll 1
Domestic Mediumhair 1
Terrier - Yorkshire 1
Ridgeback - Rhodesian 1
Domestic Longhair 1

Associated Drugs

Robenacoxib 4
Diphenhydramine 4
Trilostane 3
Feline Rhinotracheitis-Calici-Panleukopenia Vaccine, Killed Virus 2
Rabies Vaccine 2
Famotidine 2
Maropitant Citrate 2
Fluid Therapy 2
Doxycycline 2
Dexamethasone Sodium Phosphate 2
Prednisolone 2
Bexagliflozin 2
Meloxicam 1
Chlamydia Psittaci,905,Killed + Feline Calicivirus,F-9,Live + Feline Panleukopenia Virus,Johnson Leopard Origin,Live + Feline Rhinotracheitis Virus,F2,Live + Rabies Virus,Vcp65A,Rentschler,Vector 1
Milbemycin Oxime + Praziquantel 1
Fluralaner 1
Frunevetmab 1
Fluralaner 13.64% 12-Week Chew 1
Milbemycin Oxime, Praziquantel 1
Oclacitinib 1

Low liver enzymes NOS Reaction Insights

12 reports name Low liver enzymes NOS; 1 recorded a death outcome (8.3% of reported events, not a population-level mortality rate). VeDDRA code: 2689.

By species: Cat (6 reports), Dog (6 reports). By breed: Domestic Shorthair (3), Spaniel - King Charles Cavalier (2), Schnauzer (unspecified) (2).

Most co-reported drugs: Robenacoxib (4 reports), Diphenhydramine (4 reports), Trilostane (3 reports), Feline Rhinotracheitis-Calici-Panleukopenia Vaccine, Killed Virus (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.