Reaction profile

The FDA adverse-event record for limb amputation

20 FDA adverse-event reports reference limb amputation (VeDDRA 2896). See the species, breeds, and drugs most associated with it below.

20
reports citing this reaction
5.0%
death-coded share
Cat
most-affected species
Buprenorphine
most-associated drug
Verify with FDA CVM →
20
Total Reports
1
Deaths
5.0%
Death Rate

Species Most Affected

Cat 15
Dog 5

Breeds Most Affected

Domestic Shorthair 7
Domestic Longhair 5
American Bobtail 2
Shepherd Dog - Anatolian 1
Dog (unknown) 1
Pointing Dog - Hungarian Short-haired (Vizsla) 1
Cat (other) 1
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Mountain Dog - Bernese 1

Associated Drugs

Buprenorphine 18
Maropitant Citrate 11
Propofol 11
Gabapentin 11
Ketamine 10
Dexmedetomidine 9
Cefovecin Sodium 8
Robenacoxib 8
Isoflurane 7
Fluid Therapy 7
Diphenhydramine 6
Butorphanol 6
Meloxicam 5
Methadone 5
Rabies Vaccine, Killed Virus 4
Rabies Vaccine 4
Midazolam 4
Bupivacaine 4
Tigilanol Tiglate 3
Anesthetic (Unknown) 3

Limb amputation Reaction Insights

20 reports name Limb amputation; 1 recorded a death outcome (5.0% of reported events, not a population-level mortality rate). VeDDRA code: 2896.

By species: Cat (15 reports), Dog (5 reports). By breed: Domestic Shorthair (7), Domestic Longhair (5), American Bobtail (2).

Most co-reported drugs: Buprenorphine (18 reports), Maropitant Citrate (11 reports), Propofol (11 reports), Gabapentin (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.