Reaction profile

The FDA adverse-event record for limb amputation

44 FDA reports name limb amputation, a lower-volume reaction in the CVM extract (VeDDRA 2896). Plate stamps and neighbourhood peers follow.

#1806 of 2,481
by report volume (all reactions)
44
reports citing this reaction
2.3%
death-coded share
Cat
most-affected species
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Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Limb amputation has 26 reports now versus 23 in that prior snapshot: 3 more (13.0%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Limb amputation changes

FDA AER · VeDDRA plate

Code 2896 VOL-TRACE

VOL-TRACE · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 44 reports
  • DEATH-LOW 2.3%
  • MID-PACK #1806/2481
  • PHOTO-FINISH Administration device…
  • SPECIES-CAT Cat · 21
  • DRUG-LEAD Buprenorphine · 24
  • DESK-WIDE 10 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Administration device NOS, breakage (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Limb amputation

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Administration device… · near44Diabetes insipidus · near44Eye stinging · near44Flaccid muscles · near44Limb amputation · this react…44Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Limb amputation

Limb amputation: low death-coded share in the FDA AER plate

Signature read: 1 death-coded reports is a thin tail count for Limb amputation in the CVM extract. Report volume is lower-third scale: 44 named reports in the openFDA extract. Death-coded share is lower-third: 1 of 44 reports (2.3% of named reports). Nearest volume peer: Administration device NOS, breakage (±0 reports). Lead species Cat (21). Lead co-reported drug Buprenorphine (24).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Buprenorphine appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 21
Dog 5

Breeds Most Affected

Domestic Shorthair 11
Domestic Longhair 6
American Bobtail 2
Shepherd Dog - Anatolian 1
Dog (unknown) 1
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 1
Cat (other) 1
Pointing Dog - Hungarian Short-haired (Vizsla) 1
Mountain Dog - Bernese 1
Maine Coon 1

Associated Drugs

Buprenorphine 24
Robenacoxib 13
Propofol 13
Maropitant Citrate 13
Ketamine 12
Gabapentin 12
Dexmedetomidine 10
Cefovecin Sodium 9
Isoflurane 8
Fluid Therapy 7
Rabies Virus, High Cell Passage-Street Alabama Dufferin Strain 7
Diphenhydramine 6
Butorphanol 6
Meloxicam 6
Methadone 6
Bupivacaine 6
Rabies Vaccine, Killed Virus 4
Rabies Vaccine 4
Midazolam 4
Cefazolin 4

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Limb amputation (#1806 of 2,481 by report volume); death-coded 2.3%. PlainBreed reaction plate · death-coded report count stamp 1 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →