Reaction profile

The FDA adverse-event record for lacrimation decreased

22 FDA adverse-event reports reference lacrimation decreased (VeDDRA 442). See the species, breeds, and drugs most associated with it below.

22
reports citing this reaction
4.5%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
22
Total Reports
1
Deaths
4.5%
Death Rate

Species Most Affected

Dog 20
Human 1
Cat 1

Breeds Most Affected

Terrier - Yorkshire 3
Maltese 3
Shih Tzu 2
Poodle - Miniature 2
Poodle (unspecified) 2
Terrier - Jack Russell 1
Spaniel - Cocker American 1
Schnauzer (unspecified) 1
Shepherd (unspecified) 1
Pug 1

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 10
Florfenicol, Terbinafine, Betamethasone Acetate 4
Eye Lubricant 3
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 2
Cyclosporine 2
Neomycin Sulfate/Polymyxin B Sulfate/Bacitracin Zinc 2
Prednisone 2
Gabapentin 2
Maropitant Citrate 2
Amoxicillin Trihydrate/Clavulanic Acid 2
Oclacitinib Maleate 1
Ivermectin 68Mcg Pyrantel 57Mg 1
Enrofloxacin 1
Unspecified Sedatives 1
Unspecified Cleanser 1
Diazepam 1
Fluids 1
Maropitant Citrate Inj 1
Opthatalmic Ointment Containing Bacitracin, Neomycin, And Polymyxin B 1
0.3% Oxafloxacin Ophthalmic Ointment 1

Lacrimation decreased Reaction Insights

22 reports name Lacrimation decreased; 1 recorded a death outcome (4.5% of reported events, not a population-level mortality rate). VeDDRA code: 442.

By species: Dog (20 reports), Human (1 reports), Cat (1 reports). By breed: Terrier - Yorkshire (3), Maltese (3), Shih Tzu (2).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (10 reports), Florfenicol, Terbinafine, Betamethasone Acetate (4 reports), Eye Lubricant (3 reports), Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.