Reaction profile

The FDA adverse-event record for lack of heart sounds on auscultation

21 FDA adverse-event reports reference lack of heart sounds on auscultation (VeDDRA 2839). See the species, breeds, and drugs most associated with it below.

21
reports citing this reaction
61.9%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
21
Total Reports
13
Deaths
61.9%
Death Rate

Species Most Affected

Dog 18
Cat 3

Breeds Most Affected

Retriever - Labrador 6
Domestic Shorthair 2
Retriever - Golden 2
Terrier - Bull - American Pit 2
Terrier (unspecified) 1
Sheepdog - Shetland 1
Retriever - Flat-coated 1
Norwegian Forest 1
Collie - Border 1
Newfoundland 1

Associated Drugs

Bedinvetmab 8
Carprofen 5
Gabapentin 5
Medetomidine Hydrochloride, Vatinoxan Hydrochloride 3
Isoflurane 2
Butorphanol Tartrate 2
Moxidectin 2
Maropitant Citrate 2
Galliprant 2
Hydromorphone 2
Dexmedetomidine Hydrochloride Injection 1
Butorphanol Tartrate Injection 1
Sevoflourane 1
Atipamezole 1
Intravenous Fluids 1
Robenacoxib 1
Buprenorphine 1
Xylazine 1
Ketamine 1
Grapiprant 1

Lack of heart sounds on auscultation Reaction Insights

21 reports name Lack of heart sounds on auscultation; 13 recorded a death outcome (61.9% of reported events, not a population-level mortality rate). VeDDRA code: 2839.

By species: Dog (18 reports), Cat (3 reports). By breed: Retriever - Labrador (6), Domestic Shorthair (2), Retriever - Golden (2).

Most co-reported drugs: Bedinvetmab (8 reports), Carprofen (5 reports), Gabapentin (5 reports), Medetomidine Hydrochloride, Vatinoxan Hydrochloride (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.