Reaction profile

The FDA adverse-event record for lack of efficacy (protozoa) - piroplasma

41 FDA adverse-event reports reference lack of efficacy (protozoa) - piroplasma (VeDDRA 2809). See the species, breeds, and drugs most associated with it below.

41
reports citing this reaction
51.2%
death-coded share
Cat
most-affected species
Fluralaner/Moxidectin Spot-On
most-associated drug
Verify with FDA CVM →
41
Total Reports
21
Deaths
51.2%
Death Rate

Species Most Affected

Cat 36
Dog 4
Horse 1

Breeds Most Affected

Domestic Shorthair 27
Domestic Longhair 4
Domestic Mediumhair 4
Pit Bull 1
Crossbred Canine/dog 1
Pony (unspecified) 1
Retriever - Golden 1
Greyhound 1
Maine Coon 1

Associated Drugs

Fluralaner/Moxidectin Spot-On 19
Fluralaner Spot-On Solution 17
Afoxolaner 3
Imidacloprid, Moxidectin 1
Imidocarb Dipropionate Inj Sol 1
Ivermectin + Pyrantel As Pamoate Salt 1
Venlafaxine 1
Clonidine 1
Dexmedetomidine Oromucosal Gel 1
Selamectin 1
Cefovecin 1

Lack of efficacy (protozoa) - Piroplasma Reaction Insights

41 reports name Lack of efficacy (protozoa) - Piroplasma; 21 recorded a death outcome (51.2% of reported events, not a population-level mortality rate). VeDDRA code: 2809.

By species: Cat (36 reports), Dog (4 reports), Horse (1 reports). By breed: Domestic Shorthair (27), Domestic Longhair (4), Domestic Mediumhair (4).

Most co-reported drugs: Fluralaner/Moxidectin Spot-On (19 reports), Fluralaner Spot-On Solution (17 reports), Afoxolaner (3 reports), Imidacloprid, Moxidectin (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.