Reaction profile

The FDA adverse-event record for lack of efficacy (protozoa) - piroplasma

42 FDA reports name lack of efficacy (protozoa) - piroplasma, a lower-volume reaction in the CVM extract (VeDDRA 2809). Plate stamps and neighbourhood peers follow.

#1831 of 2,481
by report volume (all reactions)
42
reports citing this reaction
50.0%
death-coded share
Cat
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (protozoa) - Piroplasma has 42 reports now versus 42 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (protozoa) - Piroplasma changes

FDA AER · VeDDRA plate

Code 2809 VOL-TRACE

VOL-TRACE · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-CAT · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 42 reports
  • DEATH-HOT 50.0%
  • MID-PACK #1831/2481
  • PHOTO-FINISH Allergy to food
  • SPECIES-CAT Cat · 36
  • DRUG-LEAD Fluralaner/Moxide… · 19
  • DESK-WIDE 9 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Allergy to food (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Lack of efficacy - Piroplasma

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Allergy to food · near42Asystole · near42Cholecystitis · near42Cutaneous emphysema · near42Lack of efficacy (pro… · thi…42Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lack of efficacy (protozoa) - Piroplasma

Lack of efficacy (protozoa) - Piroplasma: high death-coded share in the FDA AER plate

Signature read: Lack of efficacy (protozoa) - Piroplasma's 50.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 42 named reports in the openFDA extract. Death-coded share is upper-third: 21 of 42 reports (50.0% of named reports). Nearest volume peer: Allergy to food (±0 reports). Lead species Cat (36). Lead co-reported drug Fluralaner/Moxidectin Spot-On (19).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cat 36
Dog 5
Horse 1

Breeds Most Affected

Domestic Shorthair 27
Domestic Longhair 4
Domestic Mediumhair 4
Greyhound 2
Pit Bull 1
Crossbred Canine/dog 1
Pony (unspecified) 1
Retriever - Golden 1
Maine Coon 1

Associated Drugs

Fluralaner/Moxidectin Spot-On 19
Fluralaner Spot-On Solution 17
Afoxolaner 4
Imidacloprid, Moxidectin 1
Imidocarb Dipropionate Inj Sol 1
Ivermectin + Pyrantel As Pamoate Salt 1
Venlafaxine 1
Clonidine 1
Dexmedetomidine Oromucosal Gel 1
Selamectin 1
Cefovecin 1
Imidacloprid,Moxidectin 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (protozoa) - Piroplasma (#1831 of 2,481 by report volume); death-coded 50.0%. PlainBreed reaction plate · death-coded share stamp 50.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →