Reaction profile

The FDA adverse-event record for lack of efficacy (parvovirus)

12 FDA adverse-event reports reference lack of efficacy (parvovirus) (VeDDRA 2552). See the species, breeds, and drugs most associated with it below.

12
reports citing this reaction
8.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Praziquantel
most-associated drug
Verify with FDA CVM →
12
Total Reports
1
Deaths
8.3%
Death Rate

Species Most Affected

Dog 12

Breeds Most Affected

Dachshund - Miniature 2
Retriever - Labrador 2
Retriever - Golden 2
Pit Bull 1
Rottweiler 1
Shepherd Dog - Australian 1
Bulldog - American 1
Chihuahua 1
Boxer (German Boxer) 1

Associated Drugs

Milbemycin Oxime + Praziquantel 8
Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 5
Milbemycin Oxime + Spinosad 5
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus 4
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 3
Rabies Vaccine, Killed Virus 2
Afoxolaner 2
Rabies Vaccine 2
Pyrantel Pamoate 2
Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Mlv-Kv, Leptospira Canicola-Grippotyphosa-Ictero-Pomona Bacterial Extract 2
Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus 2
Ivermectin + Pyrantel As Pamoate Salt 1
Bordetella Bronchiseptica Vaccine, Avirulent Live Culture 1
Distemper Vaccine 1
Fenbendazole 1
Fluralaner 1
Milbemycin Oxime 1
Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 1
Canine Adenovirus Type 2 + Parainfluenza + Bordetella Bronchiseptica Vaccine 1
Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus 1

Lack of efficacy (parvovirus) Reaction Insights

12 reports name Lack of efficacy (parvovirus); 1 recorded a death outcome (8.3% of reported events, not a population-level mortality rate). VeDDRA code: 2552.

By species: Dog (12 reports). By breed: Dachshund - Miniature (2), Retriever - Labrador (2), Retriever - Golden (2).

Most co-reported drugs: Milbemycin Oxime + Praziquantel (8 reports), Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract (5 reports), Milbemycin Oxime + Spinosad (5 reports), Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.