Reaction profile

The FDA adverse-event record for lack of efficacy (parvovirus)

Name: Lack of efficacy (parvovirus) - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

12 FDA reports name lack of efficacy (parvovirus), a lower-volume reaction in the CVM extract (VeDDRA 2552). Plate stamps and neighbourhood peers follow.

#2387 of 2,481
by report volume (all reactions): 12
reports citing this reaction: 8.3%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (parvovirus) has 12 reports now versus 12 in that prior snapshot: 0 the same number of (0.0%).

Report change: +0
Death-coded reports: +0
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (parvovirus) changes

FDA AER · VeDDRA plate

Code 2552 VOL-TRACE

VOL-TRACE · DEATH-PAR · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 12 reports
DEATH-PAR 8.3%
BOTTOM-DECILE #2387/2481
PHOTO-FINISH Agitated state of mind
SPECIES-DOG Dog · 12
DRUG-LEAD Milbemycin Oxime… · 8
DESK-WIDE 9 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Agitated state of mind (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Lack of efficacy

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Lack of efficacy (parvovirus)

What the FDA AER plate says about Lack of efficacy (parvovirus)

Signature read: 12 reports place Lack of efficacy (parvovirus) in the lower third of FDA AER volume (#2387 of 2,481). Report volume is lower-third scale: 12 named reports in the openFDA extract. 1 of 12 reports were death-coded (8.3% of named reports, not a population mortality rate). Nearest volume peer: Agitated state of mind (±0 reports). Lead species Dog (12). Lead co-reported drug Milbemycin Oxime + Praziquantel (8).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Praziquantel appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 12

Breeds Most Affected

Dachshund - Miniature 2

Retriever - Golden 2

Retriever - Labrador 2

Pit Bull 1

Rottweiler 1

Shepherd Dog - Australian 1

Boxer (German Boxer) 1

Chihuahua 1

Bulldog - American 1

Associated Drugs

Milbemycin Oxime + Praziquantel 8

Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 5

Milbemycin Oxime + Spinosad 5

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus 4

Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Mlv, Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 3

Rabies Vaccine, Killed Virus 2

Afoxolaner 2

Rabies Vaccine 2

Pyrantel Pamoate 2

Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Mlv-Kv, Leptospira Canicola-Grippotyphosa-Ictero-Pomona Bacterial Extract 2

Canine Distemper-Adenovirus Type 2-Parvovirus Vaccine, Modified Live Virus 2

Bordetella Bronchiseptica Vaccine, Avirulent Live Culture 1

Ivermectin + Pyrantel As Pamoate Salt 1

Distemper Vaccine 1

Fenbendazole 1

Fluralaner 1

Milbemycin Oxime 1

Leptospira Canicola-Grippotyphosa-Icterohaemorrhagiae-Pomona Bacterial Extract 1

Canine Distemper-Adenovirus Type 2-Coronavirus-Parainfluenza-Parvovirus Vaccine, Modified Live And Killed Virus 1

Canine Adenovirus Type 2 + Parainfluenza + Bordetella Bronchiseptica Vaccine 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (parvovirus) (#2387 of 2,481 by report volume); death-coded 8.3%. PlainBreed reaction plate · report volume stamp 12 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →