Reaction profile

The FDA adverse-event record for lack of efficacy (endoparasite) - cyathostominae

13 FDA reports name lack of efficacy (endoparasite) - cyathostominae, a lower-volume reaction in the CVM extract (VeDDRA 2796). Plate stamps and neighbourhood peers follow.

#2359 of 2,481
by report volume (all reactions)
13
reports citing this reaction
15.4%
death-coded share
Horse
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (endoparasite) - Cyathostominae has 13 reports now versus 13 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (endoparasite) - Cyathostominae changes

FDA AER · VeDDRA plate

Code 2796 VOL-TRACE

VOL-TRACE · DEATH-ELEV · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-HORSE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 13 reports
  • DEATH-ELEV 15.4%
  • BOTTOM-DECILE #2359/2481
  • PHOTO-FINISH Abnormal digital pulse
  • SPECIES-HORSE Horse · 7
  • DRUG-LEAD Pyrantel Pamoate;… · 4
  • DESK-WIDE 11 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal digital pulse (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Lack of efficacy - Cyathostominae

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal digital pulse · near13Acute haemorrhagic pa… · near13Acute jaundice · near13Application site mass… · near13Lack of efficacy (end… · thi…13Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lack of efficacy (endoparasite) - Cyathostominae

What the FDA AER plate says about Lack of efficacy (endoparasite) - Cyathostominae

Signature read: 13 reports place Lack of efficacy (endoparasite) - Cyathostominae in the lower third of FDA AER volume (#2359 of 2,481). Report volume is lower-third scale: 13 named reports in the openFDA extract. 2 of 13 reports were death-coded (15.4% of named reports, not a population mortality rate). Nearest volume peer: Abnormal digital pulse (±0 reports). Lead species Horse (7). Lead co-reported drug Pyrantel Pamoate;Sarolaner (4).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Pyrantel Pamoate;Sarolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Horse 7
Dog 5
Cattle 1

Breeds Most Affected

Mixed (Horse) 2
Thoroughbred 2
Saddlebred - American 1
Horse (unknown) 1
Cattle (unknown) 1
Warmblood (unspecified) 1
Shih Tzu 1
Mastiff 1
Canaan Dog 1
Retriever - Golden 1

Associated Drugs

Pyrantel Pamoate;Sarolaner 4
Pyrantel Tartrate 3
Fenbendazol Oral Paste 2
Ivermectin Pour-On Cattle 1
Fenbendazole 1
Praziquantel; Moxidectin 1
Milbemycin Oxime 1
Ivermectin + Pyrantel As Pamoate Salt 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (endoparasite) - Cyathostominae (#2359 of 2,481 by report volume); death-coded 15.4%. PlainBreed reaction plate · report volume stamp 13 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →