Reaction profile

The FDA adverse-event record for labelled drug-disease interaction medication error

Name: Labelled drug-disease interaction medication error - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

24 FDA adverse-event reports reference labelled drug-disease interaction medication error (VeDDRA 99841). See the species, breeds, and drugs most associated with it below.

24
reports citing this reaction: 29.2%
death-coded share: Dog
most-affected species: Milbemycin Oxime + Spinosad
most-associated drug

Compiled by PlainBreed Editorial, Pet Health Editorial Team

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Total Reports

Deaths

29.2%

Death Rate

Species Most Affected

Dog 19

Cat 4

Cattle 1

Breeds Most Affected

Dog (unknown) 6

Crossbred Canine/dog 2

Domestic Shorthair 2

Cat (other) 2

Shepherd Dog - German 1

Retriever - Labrador 1

Pinscher - Miniature 1

Cattle (other) 1

Lhasa Apso 1

Shih Tzu 1

Associated Drugs

Milbemycin Oxime + Spinosad 5

Milbemycin Oxime 3

Butorphanol Tartrate 2

Robenacoxib 1

Unknown Anesthesia 1

Buprenorphine 1

Ketoprofen 1

Furosemide 1

Theophylline 1

Benazepril Hydrochloride 1

Meloxicam 1

Pirlimycin Hydrochloride 1

Cyclosporine A 1

Cyclosporine 1

Ketoconazole 1

Cefovecin Sodium 1

Phenobarbital 1

Mupirocin 1

Methylprednisolone Acetate 1

Trilostane 1

Labelled drug-disease interaction medication error Reaction Insights

24 reports name Labelled drug-disease interaction medication error; 7 recorded a death outcome (29.2% of reported events, not a population-level mortality rate). VeDDRA code: 99841.

By species: Dog (19 reports), Cat (4 reports), Cattle (1 reports). By breed: Dog (unknown) (6), Crossbred Canine/dog (2), Domestic Shorthair (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (5 reports), Milbemycin Oxime (3 reports), Butorphanol Tartrate (2 reports), Robenacoxib (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.