Reaction profile

The FDA adverse-event record for keratoconjunctivitis

47 FDA adverse-event reports reference keratoconjunctivitis (VeDDRA 470). See the species, breeds, and drugs most associated with it below.

47
reports citing this reaction
10.6%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
47
Total Reports
5
Deaths
10.6%
Death Rate

Species Most Affected

Dog 39
Cattle 7
Cat 1

Breeds Most Affected

Shih Tzu 6
Chihuahua 6
Spaniel - King Charles Cavalier 4
Mixed (Cattle) 3
Terrier (unspecified) 3
Spaniel (unspecified) 2
Holstein-Friesian also known as Holstein 2
Crossbred Canine/dog 2
Bulldog - French 2
Beagle 2

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 20
Oclacitinib Maleate 8
Maropitant Citrate 8
Meclizine 4
Florfenicol, Terbinafine, Betamethasone Acetate 3
Lokivetmab Injectable Solution 3
Canine Influenza Vaccine 3
Moxidectin 2
Cefpodoxime Proxetil 2
Albendazole 2
Moraxella Bovis Bacterin (Solidtech) 2
Ivermectin 2
Grapiprant 2
Gabapentin 2
Dexamethasone Sodium Phosphate 2
Diphenhydramine 2
Phenylpropanolamine Hcl 2
Glucosamine Hydrochloride/Sodium Chondroitin Sulfate/Avocado/Soybean Unsaponifiables/Boswellia Serrata Extract/Green Tea Extract Chewable 2
Probiotics 2
Oclactinib 2

Keratoconjunctivitis Reaction Insights

47 reports name Keratoconjunctivitis; 5 recorded a death outcome (10.6% of reported events, not a population-level mortality rate). VeDDRA code: 470.

By species: Dog (39 reports), Cattle (7 reports), Cat (1 reports). By breed: Shih Tzu (6), Chihuahua (6), Spaniel - King Charles Cavalier (4).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (20 reports), Oclacitinib Maleate (8 reports), Maropitant Citrate (8 reports), Meclizine (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.