Reaction profile

The FDA adverse-event record for joint oedema

35 FDA adverse-event reports reference joint oedema (VeDDRA 572). See the species, breeds, and drugs most associated with it below.

35
reports citing this reaction
22.9%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
35
Total Reports
8
Deaths
22.9%
Death Rate

Species Most Affected

Dog 26
Horse 4
Cat 4
Human 1

Breeds Most Affected

Retriever - Labrador 5
Domestic Shorthair 2
Weimaraner 2
Shepherd Dog - German 2
Boxer (German Boxer) 2
Retriever - Golden 2
Paint 1
Quarter Horse 1
Deutsche Dogge, Great Dane 1
Rottweiler 1

Associated Drugs

Carprofen 6
Enrofloxacin 5
Bedinvetmab 5
Gabapentin 3
Fluralaner Chew Tablets 3
Milbemycin Oxime + Spinosad 2
Maropitant Citrate 2
Milk Thistle 2
Chinese Herbal 2
Tramadol 2
Deracoxib 2
Moxidectin 2
Canine Da2Ppv (Orig S-P Us) Lv 2
Afoxolaner 2
Oclacitinib Maleate 2
Hyaluronate Sodium 1
Imidacloprid + Moxidectin 1
Unknown Vaccines 1
Spinosad 1
Cefovecin 1

Joint oedema Reaction Insights

35 reports name Joint oedema; 8 recorded a death outcome (22.9% of reported events, not a population-level mortality rate). VeDDRA code: 572.

By species: Dog (26 reports), Horse (4 reports), Cat (4 reports). By breed: Retriever - Labrador (5), Domestic Shorthair (2), Weimaraner (2).

Most co-reported drugs: Carprofen (6 reports), Enrofloxacin (5 reports), Bedinvetmab (5 reports), Gabapentin (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.