Reaction profile

The FDA adverse-event record for ingredient quality issue nos

18 FDA adverse-event reports reference ingredient quality issue nos (VeDDRA 93097). See the species, breeds, and drugs most associated with it below.

18
reports citing this reaction
5.6%
death-coded share
Unknown
most-affected species
Phenylbutazone
most-associated drug
Verify with FDA CVM →
18
Total Reports
1
Deaths
5.6%
Death Rate

Species Most Affected

Unknown 12
Dog 6

Breeds Most Affected

Unknown 12
Retriever - Labrador 1
Chihuahua 1
Shih Tzu 1
Maltese 1
Dog (unknown) 1
Boxer (German Boxer) 1

Associated Drugs

Phenylbutazone 5
Ivermectin 4
Miconazole Nitrate 3
Furosemide 3
Betamethasone Valerate + Gentamicin Sulfate 2
Gentamicin Sulfate 2
Milbemycin Oxime + Spinosad 2
Chondroitin Sulfate (Bovine) + Dimethyl Sulfone + Glucosamine 1
Clindamycin Hydrochloride 1
Milbemycin Oxime 1
Milbemycin Oxime + Praziquantel 1
Clorsulon + Ivermectin 1
Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate 1
Sarolaner,Moxidectin,Pyrantel 1
Spinosad 1
Cyclosporine 1
Black Pepper + Cordyceps + Docosahexaenoic Acid + Eicosapentaenoic Acid + Kelp + L-Theanine + Lions Mane + Maitake + Phellinus + Reishi + Shiitake + Tumeric Root + Turkey Tail 1

INGREDIENT QUALITY ISSUE NOS Reaction Insights

18 reports name INGREDIENT QUALITY ISSUE NOS; 1 recorded a death outcome (5.6% of reported events, not a population-level mortality rate). VeDDRA code: 93097.

By species: Unknown (12 reports), Dog (6 reports). By breed: Unknown (12), Retriever - Labrador (1), Chihuahua (1).

Most co-reported drugs: Phenylbutazone (5 reports), Ivermectin (4 reports), Miconazole Nitrate (3 reports), Furosemide (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.