Reaction profile

The FDA adverse-event record for increased testicle size

29 FDA adverse-event reports reference increased testicle size (VeDDRA 2068). See the species, breeds, and drugs most associated with it below.

29
reports citing this reaction
10.3%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
29
Total Reports
3
Deaths
10.3%
Death Rate

Species Most Affected

Dog 29

Breeds Most Affected

Retriever - Labrador 5
Shepherd Dog - German 5
Terrier - Bull - American Pit 2
Shih Tzu 2
Rottweiler 2
Shepherd Dog - Australian 1
Pit Bull 1
Terrier - Boston 1
Retriever - Golden 1
Maltese 1

Associated Drugs

Oclacitinib Maleate 6
Moxidectin 2
Meloxicam 2
Cyclosporine 2
Fluralaner Chew Tablets 2
Cefpodoxime Proxetil 2
Sarolaner 2
Maropitant Citrate 2
Metronidazole 2
Fluralaner 13.64% 12-Week Chew 2
Firocoxib 227 Mg Chewable 1
Spinosad 1
Milbemycin Oxime + Spinosad 1
Vaccines (Unknown) 1
Diphenhydramine Hcl 1
Milbemycin Oxime, Lufenuron 1
Cyclosporine A 1
Analgesic 1
Milbemycin Oxime 1
Firocoxib 1

Increased testicle size Reaction Insights

29 reports name Increased testicle size; 3 recorded a death outcome (10.3% of reported events, not a population-level mortality rate). VeDDRA code: 2068.

By species: Dog (29 reports). By breed: Retriever - Labrador (5), Shepherd Dog - German (5), Terrier - Bull - American Pit (2).

Most co-reported drugs: Oclacitinib Maleate (6 reports), Moxidectin (2 reports), Meloxicam (2 reports), Cyclosporine (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.