Reaction profile

The FDA adverse-event record for increased culls

Name: Increased culls - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

14 FDA reports name increased culls, a lower-volume reaction in the CVM extract (VeDDRA 2513). Plate stamps and neighbourhood peers follow.

#2326 of 2,481
by report volume (all reactions): 14
reports citing this reaction: 100.0%
death-coded share: Cattle
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Increased culls has 14 reports now versus 13 in that prior snapshot: 1 more (7.7%).

Report change: +1
Death-coded reports: +1
Death-coded share: +0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Increased culls changes

FDA AER · VeDDRA plate

Code 2513 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 14 reports
DEATH-HOT 100.0%
BOTTOM-DECILE #2326/2481
PHOTO-FINISH Addisonian crisis
SPECIES-CATTLE Cattle · 11
DRUG-LEAD Monensin Sodium · 5
DESK-WIDE 8 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Addisonian crisis (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Increased culls

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Increased culls

Increased culls: high death-coded share in the FDA AER plate

Signature read: Increased culls's 100.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 14 named reports in the openFDA extract. Death-coded share is upper-third: 14 of 14 reports (100.0% of named reports). Nearest volume peer: Addisonian crisis (±0 reports). Lead species Cattle (11). Lead co-reported drug Monensin Sodium (5).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 11

Turkey 2

Dog 1

Breeds Most Affected

Holstein-Friesian also known as Holstein 4

Cattle (other) 3

Turkey (unknown) 2

Mixed (Cattle) 1

Limousin 1

Dog (unknown) 1

Jersey 1

Cattle (unknown) 1

Associated Drugs

Monensin Sodium 5

Ceftiofur Hydrochloride 4

Dinoprost Tromethamine 2

Estradiol Benzoate; Testosterone Propionate 1

Estradiol Benzoate; Trenbolone Acetate 1

Melengestrol Acetate 1

Sometribove 1

Clostridium Chauvoei, Strain F, Lot No. 2-84; Clostridium Novyi, 8296, Kb; Clost 1

Trenbolone Acetate;Estradiol Benzoate 1

Febantel + Praziquantel + Pyrantel 1

Tulathromycin 1

Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 1

Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus 1

E. Coli Strain J5, Lot #072692 1

Bismuth Subnitrate 1

Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Bovine Respiratory Syncyti 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Increased culls (#2326 of 2,481 by report volume); death-coded 100.0%. PlainBreed reaction plate · death-coded share stamp 100.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →