Reaction profile

The FDA adverse-event record for implant site bleeding

22 FDA adverse-event reports reference implant site bleeding (VeDDRA 47). See the species, breeds, and drugs most associated with it below.

22
reports citing this reaction
40.9%
death-coded share
Cattle
most-affected species
Estradiol
most-associated drug
Verify with FDA CVM →
22
Total Reports
9
Deaths
40.9%
Death Rate

Species Most Affected

Cattle 13
Dog 5
Cat 2
Ferret 2

Breeds Most Affected

Dog (unknown) 4
Cattle (unknown) 3
Crossbred Bovine/Cattle 3
Mixed (Cattle) 3
Unknown 2
Siamese 1
Cattle (other) 1
Hereford cattle 1
Aberdeen Angus 1
Terrier - Yorkshire 1

Associated Drugs

Estradiol 5
Device: Catheter 4
Clostridium Chauvoei + Septicum + Novyi + Sordellii + Perfringens Types C And D + Haemophilus Somnus Vaccines 3
Ivermectin 3
Oxfendazole 3
Bovine Rhinotracheitis + Virus Diarrhea + Parainfluenza + Respiratory Syncytial Virus Vaccine + Mannheimia Haemolytica Toxoid 3
Trenbolone Acet/Estradiol Impl 2
Trenbolone Acetate;Estradiol Benzoate 2
Deslorelin Acetate 2
Polysulfated Glycosaminoglycan 1
Metoclopramide 1
Potassium Citrate 1
Methimazole 1
Amlodipine 1
Benazepril 1
Mirtazapine 1
Famotidine 1
Estradiol + Trenbolone 1
Progesterone; Estradiol Benzoate 1
Vitmain B 1

Implant site bleeding Reaction Insights

22 reports name Implant site bleeding; 9 recorded a death outcome (40.9% of reported events, not a population-level mortality rate). VeDDRA code: 47.

By species: Cattle (13 reports), Dog (5 reports), Cat (2 reports). By breed: Dog (unknown) (4), Cattle (unknown) (3), Crossbred Bovine/Cattle (3).

Most co-reported drugs: Estradiol (5 reports), Device: Catheter (4 reports), Clostridium Chauvoei + Septicum + Novyi + Sordellii + Perfringens Types C And D + Haemophilus Somnus Vaccines (3 reports), Ivermectin (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.