Reaction profile

The FDA adverse-event record for hypotonia

Name: Hypotonia - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

13 FDA reports name hypotonia, a lower-volume reaction in the CVM extract (VeDDRA 2251). Plate stamps and neighbourhood peers follow.

#2357 of 2,481
by report volume (all reactions): 13
reports citing this reaction: 30.8%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hypotonia has 13 reports now versus 11 in that prior snapshot: 2 more (18.2%).

Report change: +2
Death-coded reports: +0
Death-coded share: −5.6 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hypotonia changes

FDA AER · VeDDRA plate

Code 2251 VOL-TRACE

VOL-TRACE · DEATH-HOT · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-TRACE 13 reports
DEATH-HOT 30.8%
BOTTOM-DECILE #2357/2481
PHOTO-FINISH Abnormal digital pulse
SPECIES-DOG Dog · 8
DRUG-LEAD Bedinvetmab · 4
DESK-WIDE 10 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal digital pulse (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Hypotonia

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

FDA AER report volume · neighbourhood around Hypotonia

Hypotonia: high death-coded share in the FDA AER plate

Signature read: 13 reports place Hypotonia in the lower third of FDA AER volume (#2357 of 2,481). Report volume is lower-third scale: 13 named reports in the openFDA extract. Death-coded share is upper-third: 4 of 13 reports (30.8% of named reports). Nearest volume peer: Abnormal digital pulse (±0 reports). Lead species Dog (8). Lead co-reported drug Bedinvetmab (4).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 8

Cat 3

Horse 1

Pig 1

Breeds Most Affected

Domestic Shorthair 3

Siberian Husky 2

Cattle Dog - Flanders (Bouvier) 1

Retriever - Labrador 1

Spitz - Dutch (Keeshond) 1

Thoroughbred 1

Poodle (unspecified) 1

Retriever - Golden 1

Crossbred Porcine/Pig 1

Poodle - Standard 1

Associated Drugs

Bedinvetmab 4

Carprofen 2

Maropitant Citrate 2

Capromorelin 2

Famotidine 2

Fluid Therapy 2

Ampicillin Sodium/Sulbactam Sodium 2

Oxygen 2

Afoxolaner 136 Mg Chewable Tablets 1

Fluralaner Spot-On Solution 1

Cefovecin 1

Methylprednisolone Acetate 1

Benadryl 1

Cetirizine 1

Isoflurane 1

Potassium Chloride, Sodium Chloride 1

Calcium 1

Potassium Chloride 1

Dobutamine 1

Morphine 1

What to do with this reaction

Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hypotonia (#2357 of 2,481 by report volume); death-coded 30.8%. PlainBreed reaction plate · report volume stamp 13 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →