Reaction profile

The FDA adverse-event record for hypopyon

16 FDA reports name hypopyon, a lower-volume reaction in the CVM extract (VeDDRA 419). Plate stamps and neighbourhood peers follow.

#2274 of 2,481
by report volume (all reactions)
16
reports citing this reaction
12.5%
death-coded share
Cattle
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hypopyon has 16 reports now versus 16 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hypopyon changes

FDA AER · VeDDRA plate

Code 419 VOL-TRACE

VOL-TRACE · DEATH-ELEV · BOTTOM-DECILE · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 16 reports
  • DEATH-ELEV 12.5%
  • BOTTOM-DECILE #2274/2481
  • PHOTO-FINISH Abdominal transudate
  • SPECIES-CATTLE Cattle · 6
  • DRUG-LEAD Ceftiofur Crystal… · 5
  • DESK-WIDE 10 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abdominal transudate (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Hypopyon

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abdominal transudate · near16Abnormal rectal palpa… · near16AMMONIA INCREASED, BL… · near16Application site gran… · near16Hypopyon · this reaction16Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hypopyon

What the FDA AER plate says about Hypopyon

Signature read: 16 reports place Hypopyon in the lower third of FDA AER volume (#2274 of 2,481). Report volume is lower-third scale: 16 named reports in the openFDA extract. 2 of 16 reports were death-coded (12.5% of named reports, not a population mortality rate). Nearest volume peer: Abdominal transudate (±0 reports). Lead species Cattle (6). Lead co-reported drug Ceftiofur Crystalline Free Acid (5).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ceftiofur Crystalline Free Acid appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 6
Cat 5
Dog 3
Horse 2

Breeds Most Affected

Holstein-Friesian also known as Holstein 4
Domestic Shorthair 3
Cattle (other) 2
Pinscher - Miniature 1
Paint 1
Retriever (unspecified) 1
Siberian 1
Quarter Horse 1
Spaniel - King Charles Cavalier 1
Domestic Mediumhair 1

Associated Drugs

Ceftiofur Crystalline Free Acid 5
Robenacoxib 3
Buprenorphine 2
Hyaluronate Sodium 1
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Triple Antibiotic 1
Insulin 1
Phenobarbital 1
Gentamicin Sulfate 1
Diphenhydramine Hcl 1
Ofloxacin 1
Anesthetic 1
Saline 1
Prednisone 1
Dorzolamide Hcl 1
Diclofenac 1
Tramadol 1
Polysulfated Glycosaminoglycan 1
Phenylbutazone 1
Milbemycin Oxime + Spinosad 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hypopyon (#2274 of 2,481 by report volume); death-coded 12.5%. PlainBreed reaction plate · report volume stamp 16 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →