Reaction profile

The FDA adverse-event record for hypopyon

16 FDA adverse-event reports reference hypopyon (VeDDRA 419). See the species, breeds, and drugs most associated with it below.

16
reports citing this reaction
12.5%
death-coded share
Cattle
most-affected species
Ceftiofur Crystalline Free Acid
most-associated drug
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16
Total Reports
2
Deaths
12.5%
Death Rate

Species Most Affected

Cattle 6
Cat 5
Dog 3
Horse 2

Breeds Most Affected

Holstein-Friesian also known as Holstein 4
Domestic Shorthair 3
Cattle (other) 2
Pinscher - Miniature 1
Paint 1
Retriever (unspecified) 1
Siberian 1
Quarter Horse 1
Spaniel - King Charles Cavalier 1
Domestic Mediumhair 1

Associated Drugs

Ceftiofur Crystalline Free Acid 5
Robenacoxib 3
Buprenorphine 2
Hyaluronate Sodium 1
Amoxicillin Trihydrate; Clavulanate Potassium ( K-Clavulanate) 1
Triple Antibiotic 1
Insulin 1
Phenobarbital 1
Gentamicin Sulfate 1
Diphenhydramine Hcl 1
Ofloxacin 1
Anesthetic 1
Saline 1
Prednisone 1
Dorzolamide Hcl 1
Diclofenac 1
Tramadol 1
Polysulfated Glycosaminoglycan 1
Phenylbutazone 1
Milbemycin Oxime + Spinosad 1

Hypopyon Reaction Insights

16 reports name Hypopyon; 2 recorded a death outcome (12.5% of reported events, not a population-level mortality rate). VeDDRA code: 419.

By species: Cattle (6 reports), Cat (5 reports), Dog (3 reports). By breed: Holstein-Friesian also known as Holstein (4), Domestic Shorthair (3), Cattle (other) (2).

Most co-reported drugs: Ceftiofur Crystalline Free Acid (5 reports), Robenacoxib (3 reports), Buprenorphine (2 reports), Hyaluronate Sodium (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.