Reaction profile

The FDA adverse-event record for hyperparathyroidism

21 FDA reports name hyperparathyroidism, a lower-volume reaction in the CVM extract (VeDDRA 397). Plate stamps and neighbourhood peers follow.

#2142 of 2,481
by report volume (all reactions)
21
reports citing this reaction
19.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hyperparathyroidism has 21 reports now versus 21 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hyperparathyroidism changes

FDA AER · VeDDRA plate

Code 397 VOL-TRACE

VOL-TRACE · DEATH-ELEV · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 21 reports
  • DEATH-ELEV 19.0%
  • LOWER-Q #2142/2481
  • PHOTO-FINISH Chewing - pruritus
  • SPECIES-DOG Dog · 21
  • DRUG-LEAD Trilostane · 7
  • DESK-WIDE 17 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Chewing - pruritus (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Hyperparathyroidism

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Chewing - pruritus · near21Deterioration of musc… · near21External teat disorder · near21Heart disorder aggrav… · near21Hyperparathyroidism · this r…21Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hyperparathyroidism

What the FDA AER plate says about Hyperparathyroidism

Signature read: 21 reports place Hyperparathyroidism in the lower third of FDA AER volume (#2142 of 2,481). Report volume is lower-third scale: 21 named reports in the openFDA extract. 4 of 21 reports were death-coded (19.0% of named reports, not a population mortality rate). Nearest volume peer: Chewing - pruritus (±0 reports). Lead species Dog (21). Lead co-reported drug Trilostane (7).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Trilostane appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 21

Breeds Most Affected

Terrier - Jack Russell 2
Crossbred Canine/dog 2
Retriever - Golden 2
Shepherd Dog - Australian 2
Terrier - Yorkshire 1
Bichon Frise 1
Collie (unspecified) 1
Dog (unknown) 1
Boxer (German Boxer) 1
Collie - Smooth-haired 1

Associated Drugs

Trilostane 7
Milbemycin Oxime + Praziquantel 3
Oclacitinib Maleate 3
Bedinvetmab 3
Milbemycin Oxime + Spinosad 2
Cosequin 2
Fish Oil Supplement 2
Firocoxib 1
Fluralaner Chew Tablets 1
Fluralaner 1
Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate 1
Capromorelin 1
Oclacitinib 1
Grapiprant 1
Anti-Il31 Mab Mcs Lot #1283563 1
Polysulfated Glycosaminoglycan 1
Carprofen 1
Apomorphine 1
Hydrogen Peroxide 1
Fluids 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hyperparathyroidism (#2142 of 2,481 by report volume); death-coded 19.0%. PlainBreed reaction plate · report volume stamp 21 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →