Reaction profile

The FDA adverse-event record for hypernatraemia

39 FDA reports name hypernatraemia, a lower-volume reaction in the CVM extract (VeDDRA 2511). Plate stamps and neighbourhood peers follow.

#1862 of 2,481
by report volume (all reactions)
39
reports citing this reaction
15.4%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hypernatraemia has 39 reports now versus 11 in that prior snapshot: 28 more (254.5%).

Report change
+28
Death-coded reports
+3
Death-coded share
−11.9 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hypernatraemia changes

FDA AER · VeDDRA plate

Code 2511 VOL-TRACE

VOL-TRACE · DEATH-ELEV · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 39 reports
  • DEATH-ELEV 15.4%
  • LOWER-Q #1862/2481
  • PHOTO-FINISH Adaptor, missing
  • SPECIES-DOG Dog · 25
  • DRUG-LEAD Maropitant Citrate · 11
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Adaptor, missing (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around Hypernatraemia

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Adaptor, missing · near39Adrenal gland tumour · near39Cardiopathy · near39CAT SCAN ABNORMAL · near39Hypernatraemia · this reacti…39Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hypernatraemia

What the FDA AER plate says about Hypernatraemia

Signature read: 39 reports place Hypernatraemia in the lower third of FDA AER volume (#1862 of 2,481). Report volume is lower-third scale: 39 named reports in the openFDA extract. 6 of 39 reports were death-coded (15.4% of named reports, not a population mortality rate). Nearest volume peer: Adaptor, missing (±0 reports). Lead species Dog (25). Lead co-reported drug Maropitant Citrate (11).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Maropitant Citrate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 25
Cat 14

Breeds Most Affected

Domestic Shorthair 11
Retriever - Golden 3
Shih Tzu 2
Shepherd Dog - Belgian Malinois 2
Chihuahua 2
Crossbred Canine/dog 2
Retriever - Labrador 2
Terrier (unspecified) 1
Maltese 1
Beagle 1

Associated Drugs

Maropitant Citrate 11
Trilostane 8
Gabapentin 8
Bedinvetmab 6
Ondansetron 6
Rabies Vaccine 4
Fluid Therapy (Unknown) 4
Afoxolaner 3
Velagliflozin Proline Monohydrate 3
Frunevetmab 3
Mirtazapine 3
Anti-Il31 Mab Mcs Lot #1283563 3
Fluid Therapy 3
Propofol 3
Ketamine 3
Glycopyrrolate 3
Carprofen 2
Ursodiol 2
Capromorelin 2
Molidustat Sodium 2

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hypernatraemia (#1862 of 2,481 by report volume); death-coded 15.4%. PlainBreed reaction plate · report volume stamp 39 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →