Reaction profile

The FDA adverse-event record for hyperkalemic condition

19 FDA adverse-event reports reference hyperkalemic condition (VeDDRA 1944). See the species, breeds, and drugs most associated with it below.

19
reports citing this reaction
36.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
19
Total Reports
7
Deaths
36.8%
Death Rate

Species Most Affected

Dog 14
Cat 5

Breeds Most Affected

Domestic Shorthair 3
Pug 2
Retriever - Golden 2
Shih Tzu 1
Terrier - Jack Russell 1
Retriever - Labrador 1
Poodle - Standard 1
Schnauzer - Miniature 1
Siamese 1
Terrier - West Highland White 1

Associated Drugs

Milbemycin Oxime + Spinosad 5
Grapiprant 4
Cyclosporine 3
Deracoxib 3
Robenacoxib 3
Prednisone 3
Desoxycorticosterone Pivalate 2
Fluralaner 2
Fish Oil 2
Buprenorphine 2
Isoflurane 2
Sodium Chloride + Sodium Lactate + Potassium Chloride + Calcium Chloride 2
Desoxycortone 2
Tramadol 2
Prednisolone Trimeprazine Tartrate 1
Diphenhydramine 1
Hydroxyzine 1
Antihistamine (Unknown) 1
Avocado/Soybean Unsaponifiable + Glucosamine + Sodium Chondroitin Sulfate 1
Ivermectin 1

Hyperkalemic condition Reaction Insights

19 reports name Hyperkalemic condition; 7 recorded a death outcome (36.8% of reported events, not a population-level mortality rate). VeDDRA code: 1944.

By species: Dog (14 reports), Cat (5 reports). By breed: Domestic Shorthair (3), Pug (2), Retriever - Golden (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (5 reports), Grapiprant (4 reports), Cyclosporine (3 reports), Deracoxib (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.