Reaction profile
The FDA adverse-event record for high trypsin-like immunoreactivity (tli)
33 FDA reports name high trypsin-like immunoreactivity (tli), a lower-volume reaction in the CVM extract (VeDDRA 2693). Plate stamps and neighbourhood peers follow.
- #1941 of 2,481
- by report volume (all reactions)
- 33
- reports citing this reaction
- 12.1%
- death-coded share
- Dog
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. High trypsin-like immunoreactivity (TLI) has 33 reports now versus 31 in that prior snapshot: 2 more (6.5%).
- Report change
- +2
- Death-coded reports
- +0
- Death-coded share
- −0.8 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to High trypsin-like immunoreactivity (TLI) changesFDA AER · VeDDRA plate
Code 2693 VOL-TRACE
VOL-TRACE · DEATH-ELEV · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-TRACE 33 reports
- DEATH-ELEV 12.1%
- LOWER-Q #1941/2481
- PHOTO-FINISH Abnormal dexamethason…
- SPECIES-DOG Dog · 23
- DRUG-LEAD Bedinvetmab · 6
- DESK-WIDE 20 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: Abnormal dexamethasone suppression test (±0 reports)
Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.
Lower-volume neighbourhood around High trypsin-like immunoreactivity
Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.
What the FDA AER plate says about High trypsin-like immunoreactivity (TLI)
Signature read: 33 reports place High trypsin-like immunoreactivity (TLI) in the lower third of FDA AER volume (#1941 of 2,481). Report volume is lower-third scale: 33 named reports in the openFDA extract. 4 of 33 reports were death-coded (12.1% of named reports, not a population mortality rate). Nearest volume peer: Abnormal dexamethasone suppression test (±0 reports). Lead species Dog (23). Lead co-reported drug Bedinvetmab (6).
Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
What to do with this reaction
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →