Reaction profile

The FDA adverse-event record for high trypsin-like immunoreactivity (tli)

30 FDA adverse-event reports reference high trypsin-like immunoreactivity (tli) (VeDDRA 2693). See the species, breeds, and drugs most associated with it below.

30
reports citing this reaction
13.3%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
30
Total Reports
4
Deaths
13.3%
Death Rate

Species Most Affected

Dog 22
Cat 8

Breeds Most Affected

Domestic Shorthair 8
Boxer (German Boxer) 2
Shepherd Dog - Australian 2
Crossbred Canine/dog 2
Retriever - Labrador 2
Maltese 1
Great Pyrenees 1
Deutsche Dogge, Great Dane 1
Shar Pei 1
Terrier - Irish Soft-coated Wheaten 1

Associated Drugs

Bedinvetmab 6
Maropitant Citrate 5
Metronidazole 4
Oclacitinib Maleate 3
Miconazole/Polymyxin B/Prednisolone 3
Ivermectin + Pyrantel As Pamoate Salt 2
Insulin Injectable Vial 2
Frunevetmab 2
Prescription Diet 2
Galliprant 2
Milbemycin Oxime 2
Velagliflozin Proline Monohydrate 2
Trilostane 2
Sarolaner 1
Clomipramine Hydrochloride 1
Imidacloprid, Moxidectin 1
Flumethrin + Imidacloprid 1
Dish Detergent 1
Zinc Supplement] 1
Probiotic (Unknown) 1

High trypsin-like immunoreactivity (TLI) Reaction Insights

30 reports name High trypsin-like immunoreactivity (TLI); 4 recorded a death outcome (13.3% of reported events, not a population-level mortality rate). VeDDRA code: 2693.

By species: Dog (22 reports), Cat (8 reports). By breed: Domestic Shorthair (8), Boxer (German Boxer) (2), Shepherd Dog - Australian (2).

Most co-reported drugs: Bedinvetmab (6 reports), Maropitant Citrate (5 reports), Metronidazole (4 reports), Oclacitinib Maleate (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.