Reaction profile

The FDA adverse-event record for high thyroid stimulating hormone (tsh)

36 FDA adverse-event reports reference high thyroid stimulating hormone (tsh) (VeDDRA 2703). See the species, breeds, and drugs most associated with it below.

36
reports citing this reaction
5.6%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
36
Total Reports
2
Deaths
5.6%
Death Rate

Species Most Affected

Dog 31
Cat 4
Human 1

Breeds Most Affected

Retriever - Labrador 4
Domestic Shorthair 3
Schnauzer - Miniature 3
Beagle 3
Dachshund - Standard Long-haired 3
Crossbred Canine/dog 2
Mixed (Dog) 2
Dachshund (unspecified) 2
Poodle - Standard 1
Shepherd Dog - Australian 1

Associated Drugs

Trilostane 8
Oclacitinib Maleate 5
Gabapentin 4
Anti-Il31 Mab Mcs Lot #1283563 4
Bedinvetmab 4
Levothyroxine Sodium 3
Insulin Injectable Vial 3
Fluralaner 13.64% 12-Week Chew 3
Thiamazole 2
S-Adenosylmethionine + Silybin 2
Maropitant Citrate 2
Levothyroxine Sodium, Usp 2
Fluralaner 2
Afoxolaner 2
Penobarbital 2
Frunevetmab 2
Levothyroxine 2
Meloxicam 1
Fluralaner Chew Tablets 1
Fluralaner 13.64% Chew Tablets 1

High thyroid stimulating hormone (TSH) Reaction Insights

36 reports name High thyroid stimulating hormone (TSH); 2 recorded a death outcome (5.6% of reported events, not a population-level mortality rate). VeDDRA code: 2703.

By species: Dog (31 reports), Cat (4 reports), Human (1 reports). By breed: Retriever - Labrador (4), Domestic Shorthair (3), Schnauzer - Miniature (3).

Most co-reported drugs: Trilostane (8 reports), Oclacitinib Maleate (5 reports), Gabapentin (4 reports), Anti-Il31 Mab Mcs Lot #1283563 (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.