Reaction profile

The FDA adverse-event record for hepatic vascular disorder

31 FDA reports name hepatic vascular disorder, a lower-volume reaction in the CVM extract (VeDDRA 502). Plate stamps and neighbourhood peers follow.

#1975 of 2,481
by report volume (all reactions)
31
reports citing this reaction
32.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hepatic vascular disorder has 31 reports now versus 31 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hepatic vascular disorder changes

FDA AER · VeDDRA plate

Code 502 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 31 reports
  • DEATH-HOT 32.3%
  • LOWER-Q #1975/2481
  • PHOTO-FINISH ABNORMAL TEST RESULT,…
  • SPECIES-DOG Dog · 29
  • DRUG-LEAD Milbemycin Oxime… · 11
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: ABNORMAL TEST RESULT, THYROID NOS (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Hepatic vascular disorder

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348ABNORMAL TEST RESULT,… · near31ALBUMIN HIGH, URINE · near31BILE ACIDS ABNORMAL,… · near31Clonic seizure · near31Hepatic vascular diso… · thi…31Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hepatic vascular disorder

Hepatic vascular disorder: high death-coded share in the FDA AER plate

Signature read: 31 reports place Hepatic vascular disorder in the lower third of FDA AER volume (#1975 of 2,481). Report volume is lower-third scale: 31 named reports in the openFDA extract. Death-coded share is upper-third: 10 of 31 reports (32.3% of named reports). Nearest volume peer: ABNORMAL TEST RESULT, THYROID NOS (±0 reports). Lead species Dog (29). Lead co-reported drug Milbemycin Oxime + Spinosad (11).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 29
Cat 1
Cattle 1

Breeds Most Affected

Retriever - Labrador 4
Shih Tzu 3
Terrier - Yorkshire 2
Beagle 2
Chihuahua 1
Maltese 1
Boxer (German Boxer) 1
Doberman Pinscher 1
Schnauzer - Miniature 1
Rottweiler 1

Associated Drugs

Milbemycin Oxime + Spinosad 11
Carprofen 3
Afoxolaner 3
Trilostane 3
Imidacloprid + Moxidectin 2
Prednisone 2
Ivermectin + Pyrantel As Pamoate Salt 2
Oclacitinib Maleate 2
Milbemycin Oxime + Praziquantel 2
Pyrantel Pamoate;Sarolaner 2
Neomycin Sulfate 1
Lactulose 1
Ivermectin 68Mcg, Pyrantel Pamoate 57Mg, Praziquantel 57Mg 1
Dinotefuran, Permethrin, Pyriproxyfen 1
Cephalexin 1
Sucralfate 1
Azathioprine 1
Ciprofloxacin Hcl 1
Doxycycline 1
Furosemide 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hepatic vascular disorder (#1975 of 2,481 by report volume); death-coded 32.3%. PlainBreed reaction plate · report volume stamp 31 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →