Reaction profile

The FDA adverse-event record for hepatic toxicosis

47 FDA reports name hepatic toxicosis, a lower-volume reaction in the CVM extract (VeDDRA 492). Plate stamps and neighbourhood peers follow.

#1772 of 2,481
by report volume (all reactions)
47
reports citing this reaction
46.8%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hepatic toxicosis has 47 reports now versus 47 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hepatic toxicosis changes

FDA AER · VeDDRA plate

Code 492 VOL-TRACE

VOL-TRACE · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 47 reports
  • DEATH-HOT 46.8%
  • MID-PACK #1772/2481
  • PHOTO-FINISH Abnormal number of of…
  • SPECIES-DOG Dog · 43
  • DRUG-LEAD Carprofen · 20
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal number of offspring (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Hepatic toxicosis

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal number of of… · near47ALBUMIN/GLOBULIN RATI… · near47ANISOCYTOSIS · near47Blood in trachea · near47Hepatic toxicosis · this rea…47Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hepatic toxicosis

Hepatic toxicosis: high death-coded share in the FDA AER plate

Signature read: Hepatic toxicosis's 46.8% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 47 named reports in the openFDA extract. Death-coded share is upper-third: 22 of 47 reports (46.8% of named reports). Nearest volume peer: Abnormal number of offspring (±0 reports). Lead species Dog (43). Lead co-reported drug Carprofen (20).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 43
Cat 3
Goat 1

Breeds Most Affected

Retriever - Labrador 12
Beagle 3
Retriever - Golden 3
Bulldog 2
Mountain Dog - Bernese 2
Terrier (unspecified) 2
Shepherd Dog - German 1
Terrier - Cairn 1
Rottweiler 1
Deutsche Dogge, Great Dane 1

Associated Drugs

Carprofen 20
Gabapentin 6
Maropitant Citrate 5
Grapiprant 4
Spinosad 3
Famotidine 3
Afoxolaner 3
Milbemycin Oxime + Spinosad 3
Metronidazole 3
Ketoconazole 3
Oclacitinib Maleate 3
Imidacloprid + Moxidectin 2
Ivermectin + Pyrantel As Pamoate Salt 2
Meloxicam 2
Divested Neometeoryl Transruminal & Oral Solution 2
Itraconazole 2
Trilostane 2
Maropitant 2
Amoxicillin 2
Balanced Electrolyte Solution 2

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hepatic toxicosis (#1772 of 2,481 by report volume); death-coded 46.8%. PlainBreed reaction plate · death-coded share stamp 46.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →