Reaction profile

The FDA adverse-event record for hepatic failure

44 FDA reports name hepatic failure, a lower-volume reaction in the CVM extract (VeDDRA 497). Plate stamps and neighbourhood peers follow.

#1805 of 2,481
by report volume (all reactions)
44
reports citing this reaction
77.3%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hepatic failure has 44 reports now versus 43 in that prior snapshot: 1 more (2.3%).

Report change
+1
Death-coded reports
+1
Death-coded share
+0.5 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hepatic failure changes

FDA AER · VeDDRA plate

Code 497 VOL-TRACE

VOL-TRACE · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 44 reports
  • DEATH-HOT 77.3%
  • MID-PACK #1805/2481
  • PHOTO-FINISH Administration device…
  • SPECIES-DOG Dog · 37
  • DRUG-LEAD Carprofen · 11
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Administration device NOS, breakage (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Hepatic failure

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Administration device… · near44Diabetes insipidus · near44Eye stinging · near44Flaccid muscles · near44Hepatic failure · this react…44Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hepatic failure

Hepatic failure: high death-coded share in the FDA AER plate

Signature read: Hepatic failure's 77.3% death-coded share is among the highest in the openFDA reaction corpus. Report volume is lower-third scale: 44 named reports in the openFDA extract. Death-coded share is upper-third: 34 of 44 reports (77.3% of named reports). Nearest volume peer: Administration device NOS, breakage (±0 reports). Lead species Dog (37). Lead co-reported drug Carprofen (11).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 37
Cat 7

Breeds Most Affected

Retriever - Labrador 11
Collie - Border 3
Crossbred Canine/dog 3
Terrier - Jack Russell 2
Spaniel - Cocker American 2
Domestic Shorthair 2
Cat (unknown) 2
Domestic Mediumhair 2
Unknown 2
Maine Coon 1

Associated Drugs

Carprofen 11
Cyclosporine A 4
Fluralaner Chew Tablets 3
Firocoxib 57 Mg Chewable 2
Spinosad 2
Ivermectin 2
Pradofloxacin 2
Maropitant Citrate 2
Famotidine 2
Gabapentin 2
Cyclosporine 1
Allergy Injections 1
Melarsomine Dihydrochloride Injection 1
Ivermectin + Pyrantel 1
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 1
Firocoxib 227 Mg Chewable 1
Lufenuron + Milbemycin Oxime 1
Cephalexin 1
Glucoasmine Supplement 1
Deracoxib 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hepatic failure (#1805 of 2,481 by report volume); death-coded 77.3%. PlainBreed reaction plate · death-coded share stamp 77.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →