Reaction profile

The FDA adverse-event record for heart insufficiency

33 FDA reports name heart insufficiency, a lower-volume reaction in the CVM extract (VeDDRA 200). Plate stamps and neighbourhood peers follow.

#1940 of 2,481
by report volume (all reactions)
33
reports citing this reaction
30.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Heart insufficiency has 33 reports now versus 33 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Heart insufficiency changes

FDA AER · VeDDRA plate

Code 200 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 33 reports
  • DEATH-HOT 30.3%
  • LOWER-Q #1940/2481
  • PHOTO-FINISH Abnormal dexamethason…
  • SPECIES-DOG Dog · 29
  • DRUG-LEAD Milbemycin Oxime… · 9
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal dexamethasone suppression test (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Heart insufficiency

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal dexamethason… · near33Burning mouth sensati… · near33Decreased number of s… · near33Displaced abomasum · near33Heart insufficiency · this r…33Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Heart insufficiency

Heart insufficiency: high death-coded share in the FDA AER plate

Signature read: 33 reports place Heart insufficiency in the lower third of FDA AER volume (#1940 of 2,481). Report volume is lower-third scale: 33 named reports in the openFDA extract. Death-coded share is upper-third: 10 of 33 reports (30.3% of named reports). Nearest volume peer: Abnormal dexamethasone suppression test (±0 reports). Lead species Dog (29). Lead co-reported drug Milbemycin Oxime + Spinosad (9).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 29
Cat 4

Breeds Most Affected

Terrier - Yorkshire 3
Retriever - Labrador 3
Domestic Shorthair 3
Crossbred Canine/dog 3
Bichon Frise 2
Shih Tzu 2
Pinscher - Miniature 2
Dog (unknown) 2
Retriever - Golden 1
Dog (other) 1

Associated Drugs

Milbemycin Oxime + Spinosad 9
Propofol 7
Trilostane 5
Butorphanol 4
Buprenorphine 3
Tramadol 2
Spinosad 2
Ivermectin 2
Milbemycin Oxime + Praziquantel 2
Fluralaner Chew Tablets 2
Cefovecin Sodium 2
Selamectin 2
Antibiotic (Unknown) 2
Prednisolone 2
Fenbendazole 2
Clindamycin 2
Amoxicillin 2
Doxycycline 2
Gentamicin 2
Methylprednisolone 2

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Heart insufficiency (#1940 of 2,481 by report volume); death-coded 30.3%. PlainBreed reaction plate · report volume stamp 33 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →