Reaction profile

The FDA adverse-event record for heart block 3rd degree

33 FDA reports name heart block 3rd degree, a lower-volume reaction in the CVM extract (VeDDRA 2433). Plate stamps and neighbourhood peers follow.

#1939 of 2,481
by report volume (all reactions)
33
reports citing this reaction
27.3%
death-coded share
Dog
most-affected species
Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Heart block 3rd degree has 33 reports now versus 33 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Heart block 3rd degree changes

FDA AER · VeDDRA plate

Code 2433 VOL-TRACE

VOL-TRACE · DEATH-HOT · LOWER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-TRACE 33 reports
  • DEATH-HOT 27.3%
  • LOWER-Q #1939/2481
  • PHOTO-FINISH Abnormal dexamethason…
  • SPECIES-DOG Dog · 31
  • DRUG-LEAD Isoflurane · 10
  • DESK-WIDE 17 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Abnormal dexamethasone suppression test (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Lower-volume neighbourhood around Heart block 3rd degree

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Abnormal dexamethason… · near33Burning mouth sensati… · near33Decreased number of s… · near33Displaced abomasum · near33Heart block 3rd degree · thi…33Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Heart block 3rd degree

Heart block 3rd degree: high death-coded share in the FDA AER plate

Signature read: 33 reports place Heart block 3rd degree in the lower third of FDA AER volume (#1939 of 2,481). Report volume is lower-third scale: 33 named reports in the openFDA extract. Death-coded share is upper-third: 9 of 33 reports (27.3% of named reports). Nearest volume peer: Abnormal dexamethasone suppression test (±0 reports). Lead species Dog (31). Lead co-reported drug Isoflurane (10).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 31
Human 1
Cat 1

Breeds Most Affected

Dog (unknown) 5
Crossbred Canine/dog 4
Shepherd Dog - German 4
Terrier - Boston 2
Terrier (unspecified) 2
Unknown 2
Retriever - Labrador 2
Terrier - Yorkshire 2
Shepherd Dog - Australian 2
Pit Bull 1

Associated Drugs

Isoflurane 10
Dexmedetomidine 8
Propofol 8
Dexmedetomidine Hydrochloride 8
Carprofen 7
Hydromorphone 5
Ketamine 5
Maropitant Citrate 5
Cefazolin 5
Enrofloxacin 3
Butorphanol Injectable 3
Ivermectin 2
Moxidectin 2
Doxycycline 2
Gabapentin 2
Prednisone 2
Butorphanol 2
Oclacitinib Maleate 1
Afoxolaner 136 Mg Chewable Tablets 1
Torbugesic 1

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Heart block 3rd degree (#1939 of 2,481 by report volume); death-coded 27.3%. PlainBreed reaction plate · report volume stamp 33 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →