Reaction profile

The FDA adverse-event record for heart block 1st degree

15 FDA adverse-event reports reference heart block 1st degree (VeDDRA 2431). See the species, breeds, and drugs most associated with it below.

15
reports citing this reaction
13.3%
death-coded share
Dog
most-affected species
Propofol
most-associated drug
Verify with FDA CVM →
15
Total Reports
2
Deaths
13.3%
Death Rate

Species Most Affected

Dog 15

Breeds Most Affected

Shih Tzu 2
Retriever - Golden 2
Retriever - Labrador 2
Dog (unknown) 1
Terrier - Bull - American Pit 1
Schnauzer (unspecified) 1
Collie - Border 1
Lhasa Apso 1
Shepherd Dog - German 1
Dachshund - Miniature 1

Associated Drugs

Propofol 5
Dexmedetomidine Hydrochloride 5
Butorphanol 4
Anesthetic 3
Carprofen 2
Hydromorphone Hcl 2
Isoflurane 2
Atipamezole Hydrochloride 2
Atropine 2
Meloxicam 2
Bedinvetmab 2
Pyrantel Pamoate;Sarolaner 2
Acepromazine Maleate 1
Sevoflurane 1
Canine Influenza Virus H3N8;Canine Influenza Virus H3N2 1
Polysulfated Glycosaminoglycan 1
Lufenuron + Milbemycin Oxime + Praziquantel 1
Diazepam 1
Cefazolin 1
Cefovecin 1

Heart block 1st degree Reaction Insights

15 reports name Heart block 1st degree; 2 recorded a death outcome (13.3% of reported events, not a population-level mortality rate). VeDDRA code: 2431.

By species: Dog (15 reports). By breed: Shih Tzu (2), Retriever - Golden (2), Retriever - Labrador (2).

Most co-reported drugs: Propofol (5 reports), Dexmedetomidine Hydrochloride (5 reports), Butorphanol (4 reports), Anesthetic (3 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.