Reaction profile

The FDA adverse-event record for hco3 low, blood

24 FDA adverse-event reports reference hco3 low, blood (VeDDRA 99262). See the species, breeds, and drugs most associated with it below.

24
reports citing this reaction
37.5%
death-coded share
Dog
most-affected species
Spinosad
most-associated drug
Verify with FDA CVM →
24
Total Reports
9
Deaths
37.5%
Death Rate

Species Most Affected

Dog 17
Cat 7

Breeds Most Affected

Domestic (unspecified) 6
Crossbred Canine/dog 5
Schnauzer (unspecified) 2
Griffon - Brussels 1
Poodle (unspecified) 1
Newfoundland 1
Lhasa Apso 1
Dachshund (unspecified) 1
Rottweiler 1
Setter - Irish Red 1

Associated Drugs

Spinosad 3
Meloxicam 3
Carprofen 3
Firocoxib 2
Fomepizole 1
Ivermectin, Pyrantel 1
Deracoxib 1
Maropitant 1
Desoxycorticosterone Pivalate 1
Cefovecin Sodium 1
Nitenpyram 1
Cyclosporine A 1
Robenacoxib 1
Firocoxib 227 Mg Chewable 1
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 1
Ivermectin + Pyrantel 1
Amoxicillin Anhydrous + Clavulanic Acid 1

HCO3 LOW, BLOOD Reaction Insights

24 reports name HCO3 LOW, BLOOD; 9 recorded a death outcome (37.5% of reported events, not a population-level mortality rate). VeDDRA code: 99262.

By species: Dog (17 reports), Cat (7 reports). By breed: Domestic (unspecified) (6), Crossbred Canine/dog (5), Schnauzer (unspecified) (2).

Most co-reported drugs: Spinosad (3 reports), Meloxicam (3 reports), Carprofen (3 reports), Firocoxib (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.