Reaction profile

The FDA adverse-event record for foetal death

14 FDA adverse-event reports reference foetal death (VeDDRA 2134). See the species, breeds, and drugs most associated with it below.

14
reports citing this reaction
57.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
14
Total Reports
8
Deaths
57.1%
Death Rate

Species Most Affected

Dog 9
Cat 2
Horse 1
Cattle 1
Pig 1

Breeds Most Affected

Domestic Shorthair 2
Spaniel - King Charles Cavalier 1
Terrier - Yorkshire 1
Quarter Horse 1
Poodle - Standard 1
Retriever - Golden 1
Chihuahua 1
Terrier - Cairn 1
Mountain Dog - Bernese 1
Aberdeen Angus 1

Associated Drugs

Milbemycin Oxime + Spinosad 2
Nitenpyram 2
Vitamins 1
Ivermectin 1
Carprofen 1
Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate) 1
Chlorhexidine 1
Ivermectin + Pyrantel As Pamoate Salt 1
Fipronil + Pyriproxyfen + S-Methoprene 1
Oclacitinib Maleate 1
Domperidone 1
Oxytetracycline Dihydrate 1
Tiletamine Hcl, Zolazepam Hcl 1
Lidocaine 1
Xylazine 1
Penicillin 1
Selamectin 1
Moxidectin 1
Unspecified Antihistamine 1

Foetal death Reaction Insights

14 reports name Foetal death; 8 recorded a death outcome (57.1% of reported events, not a population-level mortality rate). VeDDRA code: 2134.

By species: Dog (9 reports), Cat (2 reports), Horse (1 reports). By breed: Domestic Shorthair (2), Spaniel - King Charles Cavalier (1), Terrier - Yorkshire (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (2 reports), Nitenpyram (2 reports), Vitamins (1 reports), Ivermectin (1 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.