Reaction profile

The FDA adverse-event record for focusing difficult

Name: Focusing difficult - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://creativecommons.org/publicdomain/zero/1.0/

38 FDA adverse-event reports reference focusing difficult (VeDDRA 1479). See the species, breeds, and drugs most associated with it below.

38
reports citing this reaction: 5.3%
death-coded share: Dog
most-affected species: Milbemycin Oxime + Spinosad
most-associated drug

Compiled by PlainBreed Editorial, Pet Health Editorial Team

Verify with FDA CVM →

Total Reports

Deaths

5.3%

Death Rate

Species Most Affected

Dog 32

Cat 4

Human 1

Horse 1

Breeds Most Affected

Retriever - Labrador 6

Chihuahua 4

Shepherd Dog - German 2

Pointing Dog - Hungarian Short-haired (Vizsla) 2

Crossbred Canine/dog 2

Beagle 2

Corgi (unspecified) 1

Spitz - German Pomeranian 1

Bulldog - American 1

Poodle - Miniature 1

Associated Drugs

Milbemycin Oxime + Spinosad 10

Sarolaner 5

Afoxolaner 4

Bedinvetmab 4

Diphenhydramine 2

Meloxicam 2

Imidacloprid + Moxidectin 2

Oclacitinib Maleate 2

Fluralaner Chew Tablets 2

Pimobendan 2

Ivermectin + Pyrantel 2

Distemper Vaccine 1

Lepto Vaccine 1

Amoxicillin As Trihydrate 1

Borrelia Burgdorferi Strain Ips 930-34-081596; Borrelia Burgdorferi Strain B-31 1

Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St 1

Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 1

Diphenhydramine Hcl 1

Dexamethasone Sodium Phosphate 1

Famotidine 1

Focusing difficult Reaction Insights

38 reports name Focusing difficult; 2 recorded a death outcome (5.3% of reported events, not a population-level mortality rate). VeDDRA code: 1479.

By species: Dog (32 reports), Cat (4 reports), Human (1 reports). By breed: Retriever - Labrador (6), Chihuahua (4), Shepherd Dog - German (2).

Most co-reported drugs: Milbemycin Oxime + Spinosad (10 reports), Sarolaner (5 reports), Afoxolaner (4 reports), Bedinvetmab (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.