Reaction profile

The FDA adverse-event record for external teat disorder

21 FDA adverse-event reports reference external teat disorder (VeDDRA 537). See the species, breeds, and drugs most associated with it below.

21
reports citing this reaction
19.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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21
Total Reports
4
Deaths
19.0%
Death Rate

Species Most Affected

Dog 12
Cattle 7
Horse 1
Cat 1

Breeds Most Affected

Holstein-Friesian also known as Holstein 4
Retriever - Labrador 2
Aberdeen Angus 1
Cattle (unknown) 1
Pekingese 1
Retriever - Golden 1
Doberman Pinscher 1
Brittany 1
Boxer (German Boxer) 1
Mixed (Cattle) 1

Associated Drugs

Milbemycin Oxime + Spinosad 3
Oclacitinib Maleate 3
Estriol Tablets 3
Cyclosporine A 2
Novobiocin, Penicillin G Procaine 1
Cephapirin Sodium 1
Estradiol Benzoate, Progesterone 1
Zeranol 1
Steroid (Unknown) 1
Trimeprazine With Prednisolone 1
Amlodipine 1
Benazepril 1
Levothyroxine 1
Monensin Sodium 1
Sometribove 1
Ivermectin 1
Progesterone;Estradiol Benzoate 1
Cloxacillin Benz Intramam Dc 1
Ciclesonide 1
Febantel + Praziquantel + Pyrantel Pamoate 1

External teat disorder Reaction Insights

21 reports name External teat disorder; 4 recorded a death outcome (19.0% of reported events, not a population-level mortality rate). VeDDRA code: 537.

By species: Dog (12 reports), Cattle (7 reports), Horse (1 reports). By breed: Holstein-Friesian also known as Holstein (4), Retriever - Labrador (2), Aberdeen Angus (1).

Most co-reported drugs: Milbemycin Oxime + Spinosad (3 reports), Oclacitinib Maleate (3 reports), Estriol Tablets (3 reports), Cyclosporine A (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.