Epistaxis (bilateral)

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VeDDRA Code: 2484

29 adverse event reports referencing this reaction

29
Total Reports
8
Deaths
2760.0%
Death Rate

Species Most Affected

Dog 25
Horse 3
Cattle 1

Breeds Most Affected

Shepherd Dog - German 2
Rottweiler 2
Retriever - Labrador 2
Pit Bull 2
Brittany 2
Pony (unspecified) 1
Terrier (unspecified) 1
Bulldog 1
Newfoundland 1
Terrier - Bull - Staffordshire 1

Associated Drugs

Oclacitinib Maleate 5
Carprofen 5
Maropitant Citrate 3
Moxidectin 3
Dexmedetomidine Hydrochloride 2
Cephalexin 2
Milbemycin Oxime + Praziquantel 2
Rabies Vaccine 2
Pergolide Mesylate 2
Anti-Il31 Mab Mcs Lot #1283563 2
Afoxolaner 2
Melarsomine Dihydrochloride 2
Firocoxib 2
Trilostane 2
Polysulfated Glycosaminoglycan 2
Omeprazole 2
Propofol 2
Prednisone 2
Gabapentin 2
Butorphanol 2

Data Summary

Metric Value
Total reports referencing reaction 29
Reports with fatal outcome 8
Case-fatality rate (reported events) 2760.0%
Species observed 3
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2484.

Epistaxis (bilateral) Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 29 adverse event reports that reference Epistaxis (bilateral) as a reaction term, including 8 reports with a death outcome — a 2760.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2484, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Epistaxis (bilateral) appears most frequently in reports for Dog (25 reports), Horse (3 reports), Cattle (1 reports) — with Dog dominating at 25 entries. Within those species, the breeds most often named alongside this reaction are Shepherd Dog - German (2), Rottweiler (2), Retriever - Labrador (2). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Epistaxis (bilateral) are Oclacitinib Maleate (5 reports), Carprofen (5 reports), Maropitant Citrate (3 reports), Moxidectin (3 reports), with Oclacitinib Maleate appearing alongside this reaction in 5 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

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Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial