Reaction profile

The FDA adverse-event record for enophthalmos (see also sunken eyes in systemic disorders)

17 FDA adverse-event reports reference enophthalmos (see also sunken eyes in systemic disorders) (VeDDRA 2761). See the species, breeds, and drugs most associated with it below.

17
reports citing this reaction
23.5%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
17
Total Reports
4
Deaths
23.5%
Death Rate

Species Most Affected

Dog 16
Cat 1

Breeds Most Affected

Retriever - Labrador 4
Shepherd Dog - German 3
Chow Chow 2
Shiba Inu 1
Boxer (German Boxer) 1
Terrier (unspecified) 1
Spaniel - Springer English 1
Domestic Mediumhair 1
Terrier - Bull - Staffordshire 1
Retriever - Golden 1

Associated Drugs

Bedinvetmab 10
Oclacitinib Maleate 5
Gabapentin 4
Maropitant Citrate 4
Polysulfated Glycosaminoglycan 4
Carprofen (Unknown) 3
Tramadol 3
Pancreatic Supplement 3
Vaccines (Unknown) 3
Glucosamine (Unknown) 3
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 2
Previcox 2
Adequan 2
Propectalin 2
Yunnan Baiyao 2
Metronidazole 2
Amoxicillin Clavulanic Acid 2
Baytril 2
Anesthesia 2
Grapiprant 2

Enophthalmos (see also Sunken eyes in Systemic disorders) Reaction Insights

17 reports name Enophthalmos (see also Sunken eyes in Systemic disorders); 4 recorded a death outcome (23.5% of reported events, not a population-level mortality rate). VeDDRA code: 2761.

By species: Dog (16 reports), Cat (1 reports). By breed: Retriever - Labrador (4), Shepherd Dog - German (3), Chow Chow (2).

Most co-reported drugs: Bedinvetmab (10 reports), Oclacitinib Maleate (5 reports), Gabapentin (4 reports), Maropitant Citrate (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.