Reaction profile

The FDA adverse-event record for endotoxaemia

16 FDA adverse-event reports reference endotoxaemia (VeDDRA 2595). See the species, breeds, and drugs most associated with it below.

16
reports citing this reaction
68.8%
death-coded share
Horse
most-affected species
Ceftiofur Crystalline Free Acid
most-associated drug
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16
Total Reports
11
Deaths
68.8%
Death Rate

Species Most Affected

Horse 10
Cattle 4
Goat 1
Other Equids 1

Breeds Most Affected

Horse (unknown) 2
Welsh Cob 1
Paint 1
Goat (unknown) 1
Unknown 1
Cattle (unknown) 1
Standardbred (unspecified) 1
Crossbred Bovine/Cattle 1
Other Equids (other) 1
Cattle (other) 1

Associated Drugs

Ceftiofur Crystalline Free Acid 6
Water, Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride 3
Phenylbutazone 3
Cephapirin Benzathine 2
Dexamethasone 2
Tripelennamine Hydrochloride 2
Flunixin Meglumine Injectable 2
Omeprazole 1
Ponazuril 1
Monensin Sodium 1
Gamithromycin 1
Oxfendazole 1
Eprinomectin 1
Clostridium Chauvoei + Clostridium Novyi + Clostridium Perfringens Type C Bacterin Toxoid + Clostridium Perfringens Type D Bacterin Toxoid + Clostridium Septicum + Clostridium Sordellii 1
Bovine Parainfluenza 3 Virus, Modified Live Virus + Bovine Respiratory Syncytial Virus, Modified Live Virus + Bovine Rhinotracheitis Virus, Modified Live Virus + Bovine Virus Diarrhea Type 1, Modified Live Virus + Bovine Virus Diarrhea Type 2, Modified Live Virus + Mannheimia Haemolytica Toxoid 1
Pergolide Mesylate 1
Cloxacillin Benz Intramam Dc 1
E. Coli Strain J-5 Kb 1
Bismuth Subnitr Intramammary 1
Furosemide Injection 1

Endotoxaemia Reaction Insights

16 reports name Endotoxaemia; 11 recorded a death outcome (68.8% of reported events, not a population-level mortality rate). VeDDRA code: 2595.

By species: Horse (10 reports), Cattle (4 reports), Goat (1 reports). By breed: Horse (unknown) (2), Welsh Cob (1), Paint (1).

Most co-reported drugs: Ceftiofur Crystalline Free Acid (6 reports), Water, Sodium Chloride, Sodium Lactate, Potassium Chloride, Calcium Chloride (3 reports), Phenylbutazone (3 reports), Cephapirin Benzathine (2 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.